他汀治疗高龄男性急性冠状动脉综合征临床观察  

Clinical observation of statin treatment of very elderly male patients with acute coronary syndrome(ACS)

作　　者：盛莉[1] 肖铁卉[1] 肖文凯[1] 杨旭[1] 郑瑾[1] 叶平[1] 

机构地区：[1]解放军总医院老年心内科,北京100853

出　　处：《中华保健医学杂志》2015年第3期185-187,共3页Chinese Journal of Health Care and Medicine

基　　金：解放军总医院扶持基金(2012FC-TSYS-4006)

摘　　要：目的通过观察≥80岁高龄急性冠状动脉综合征(acute cornary syndromes,ACS)患者应用他汀的安全性和有效性,为他汀类药物合理的临床应用提供临床证据。方法选取≥80岁的高龄男性ACS患者691例,其中使用他汀者488例,非使用他汀者203例,收集两组患者相关病史、肝功能、血脂、肌酸激酶指标。结果他汀组与非他汀组相比,低密度脂蛋白胆固醇水平明显下降(P<0.05),肝功能、肌酸激酶比较差异无统计学意义(P>0.05)。他汀组患者肌酸激酶正常486例(99.4%),肌酸激酶升高患者2例(0.41%),无1例患者肌酸激酶大于10倍。他汀组肝功能正常患者473例(96.9%),丙氨酸转氨酶(ALT)>40 U/L 12例(2.54%),ALT大于3倍3例(0.61%)。结论他汀类药物用于高龄男性ACS患者是安全的,应用同时应密切监测安全性指标。Objective To evaluate the clinical safety of statin treatment in very elderly male patients with acute coronary syndrome. Methods 691 patients with ACS over age 80 were selected for the research. They were divided into two groups：statin group given Statins（n = 488）,and control group not given statin（n = 203）. Their serum levels of low-density lipoprotein cholesterol（LDL-C） were measured and their levels of alanine aminotransferase（ALT） and creatine phosphokinase（CK） were tested. Results Statin group showed decreased levels of LDL-C（P〈0.05）. There were no significant differences in 1evels of ALT and CK for both groups（P〉0.05）,compared with non-statin treatment group,statin group had 12 patients with higher level of ALT,amongst whom 3 patients had ALT levels that were 2 times higher than non-statin group;2 patients had higher levels of CK. Conclusion Statin treatment of elderly male patients with ACS is both effective and safe.

关 键 词：高龄 急性冠状动脉综合征 他汀 

分 类 号：R543.3[医药卫生—心血管疾病]