解磷定思密达联用防治有机磷中毒患者进食后反跳的发生  

Pralidoxime in combination with Smecta in prevention of rebound occurrence for patients with organophosphorus pesticide poisoning

作　　者：刘之红[1] 鞠贞会[1] 王姝红[1] 徐向英[1] 

机构地区：[1]山东省荣成市人民医院消化科,山东荣成264300

出　　处：《中国民康医学》2015年第13期9-10,87,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨解磷定与思密达联合用药治疗经口有机磷农药中毒患者在进食后导致的病情加重或病情反复。方法:将已经达到阿托品化的64例患者随机分为观察组和对照组,每组各32例,两组患者均于入院后24 h开始进食。观察组患者在进食的同时,用解磷定和思密达交替口服,两组患者的其它治疗与护理措施相同。结果:观察组患者反跳1例,对照组反跳7例,两组患者比较差异显著(P<0.05);阿托品累计用量、用机械通气例数、病程等比较差异显著(P<0.05)。结论:在患者进食的同时,交替口服解磷定和思密达,二药能分解患者胃肠内残存的毒物与代谢产物,吸附并中和含有机磷毒性成分的消化道液体,减轻中毒症状,避免反跳的发生,病程缩短,提高了治愈率。Objective： To investigate Pralidoxime in combination with Smecta in treatment of aggravated and repeated disease after organophosphorus pesticide poisoning. Methods： 64 patients having reached atropinization were randomly divided into control group（ n = 32） and observation groups（ n = 32）. 24 h after admission,all the patients began to eat and patients in the observation group recerved Pralidoxime in combination with Smecta alternatively orally took Pralidoxime and Smecta at the same time. The other treatment and nursing measures of the two group were same. Results： The rebound occurred in 1 case of observation group and 7 cases of control group,and the difference was significant（ P〈0. 05）. There were significant differences in the cumulative amount of atropine,the patient number of application of mechanical ventilation,and course of disease between the two groups（ P〈0. 05）. Conclusions： Pralidoxime and Smecta being alternatively orally taken when eating can decompose the residual organophosphate poisons and metabolites,absorb and neutralize digestive liquid containing the toxic components of organic phosphorus pesticide,reduce the symptoms of poisoning,avoid the occurrence of rebound,shorten the course of the disease,and improve the cure rate.

关 键 词：有机磷农药 中毒 反跳 解磷定 思密达 

分 类 号：R595.4[医药卫生—内科学]