特发性肺纤维化体液免疫学变化的临床意义  

Clinical significance of changes of humoral immunity in patient with idiopathic pulmonary fibrosis

作　　者：白艳玲[1] 王春媛[1] 侯衍修[1] 罗慧洁[2] 顾国忠[1] 

机构地区：[1]黑龙江省大庆油田总医院呼吸内科,黑龙江大庆163001 [2]黑龙江省大庆龙南医院呼吸内科,黑龙江大庆163458

出　　处：《中国现代医学杂志》2015年第18期41-45,共5页China Journal of Modern Medicine

基　　金：国家自然科学基金项目(No:81371439)

摘　　要：目的探讨特发性肺纤维化体液免疫学变化的临床意义。方法回顾性分析该院收治的66例特发性肺纤维化(IPF)患者,观察记录IPF患者(研究组)的临床资料,研究组进行组内比较,同时研究组与66例健康成人(对照组)的血清学资料进行对比。结果研究组和对照组血清抗体ANA、RF、CCP、ds DNA、RNP、Scl-70、Sm/RNP、SSA、SSB、PR3差异无统计学意义(P>0.05)。自身抗体阳性的IPF患者和自身抗体阴性的IPF患者在女性、有吸烟史、雷诺氏症、需要长期氧疗、6 min步行试验后低氧血症、高分辨率CT(HRCT)可见明确的普通型间质性肺炎(UIP)表现,这些方面差异均无统计学意义(P>0.05)。结论自身抗体ANA、RF、CCP、ds DNA、RNP、Scl-70、Sm/RNP、SSA、SSB、PR3的变化与特发性肺纤维化无显著相关。【Objective】To explore the clinical significance of humoral immune changes in patients with idiopathic pulmonary fibrosis（IPF）. 【Methods】 A retrospective analysis was carried out in 66 patients with IPF（research group）, the clinical data of the research group were reviewed and analyzed. The humoral immune changes of the research group and 66 cases of healthy adults（control group） were compared.【Results】There were no statistical differences in serum antibodies like ANA, RF, CCP, ds DNA, RNP, Scl-70, Sm/RNP, SSA, SSB and PR3 between the research group and the control group（P 〉 0.05）. There were no significant differences between autoantibody positive patients with IPF and autoantibody negative IPF patients in the female sex, smoking history, Raynaud’s disease,long-term oxygen therapy, hypoxemia after 6 minutes walk test or clear manifestations of usual interstitial pneumonia（UIP） by high resolution CT（HRCT, P 〉 0.05）. 【Conclusion】The changes of autoantibodies like ANA, RF, CCP,ds DNA, RNP, Scl-70, Sm/RNP, SSA, SSB and PR3 have no correlation with idiopathic pulmonary fibrosis.

关 键 词：特发性肺纤维化 自身抗体 抗核抗体 风湿因子 

分 类 号：R563.1[医药卫生—呼吸系统]