肝硬化中医证型与肝脏储备功能相关性研究  

Study on Function of Correlation between TCM Syndromes of Liver Cirrhosis and Liver Reserve

作　　者：张锦峰[1,2] 梁瑞敏[1,2] 仪文静[1,2] 

机构地区：[1]山西省中医药研究院 [2]山西省中医院肝病科,山西太原030012

出　　处：《辽宁中医杂志》2015年第7期1174-1176,共3页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:分析不同中医证型肝硬化患者的肝脏储备功能,找出中医证型与肝脏储备功能的相关性。方法:选取符合西医诊断标准及中医诊断标准的肝硬化患者,进行吲哚氰绿(ICG)清除试验检测、CTP分级、中医辨证分型。观察比较不同中医证型肝硬化患者ICG清除试验结果[血浆清除率(K)、15 min滞留率(R15)、肝脏有效血流量(EHBF)]及CTP分级情况。结果:不同中医证型的肝硬化患者中,肝郁气滞型与其他五型比较,K、R15、EHBF比较均有统计学意义;瘀血阻络型与水湿内阻型比较K、R15、EHBF有统计学意义;瘀血阻络型与湿热内蕴型比较,R15与EHBF有统计学意义;瘀血阻络型与肝肾阴虚型比较R15有统计学意义。中医证型与CTP分级具有相关性,肝气郁结型与其他五型比较均有统计学意义;肝肾阴虚型、脾肾阳虚型与其他证型比较均有统计学意义,但两证型之间比较无统计学意义,其余证型之间比较有统计意义。结论:肝硬化患者的中医证型与肝脏储备功能有相关性,中医分型能够反映临床证候趋势,可以反映肝硬化患者肝功能及肝脏储备状况、病情严重程度,具有规律性、科学性。Objective： To analyze the liver reserve function of different patients＇ syndromes of Chinese medicine,and find out the correlation between the syndrome of Chinese medicine and liver reserve function. Methods： Select liver cirrhosis who met the Western medicine and Chinese medicine diagnostic standards to participate the ICG test,CTP classification and dialectical TCMAS typing. And then observe and contrast ICG test results（ including K,R15 and EHBF） and CTP classification of liver cirrhosis in different types of Chinese medicine. Results： Compared with other five types in the stagnation of liver qi of Chinese Medicine,the results of K value,R15 and EHBF in ICG test had statistical difference. There was statistical difference in K value,R15 and EHBF in contrast of blood stasis and syndrome of internal stagnation of fluid-dampness. And also there was significant difference in R15 and EHBF compared with blood stasis and damp-heat syndrome. But there was significant difference only in R15 in contrast with blood stasis and syndrome of yin deficiency of liver and kidney. There was correlation between dialectical TCM AS typing and CTP classification,and it was significant to compare stagnation of liver qi and other five syndromes. Moreover,there＇ s statistical difference among yin deficiency of liver and kidney,yang deficiency of spleen and kidney and other syndromes. But there was no statistical difference among them. Other syndromes had significant difference. Conclusion： There＇s correlation between dialectical TCM AS typing and liver reserve function in liver cirrhosis. Liver cirrhosis dialectical TCM AS typing can reflect the clinical trend,patients＇ liver function,the status of liver reserve function and patients＇ condition. It is obvious that dialectical TCM AS typing is regular and scientific.

关 键 词：肝硬化 中医证型 肝脏储备功能 吲哚氰绿试验 CTP评分分级 

分 类 号：R657.31[医药卫生—外科学]