抗结核2SHR/6HR方案联合胸腺肽-α1治疗肠结核的疗效观察  

Curative effects of antituberculosis 2SHR/6HR chemotherapy combined with thymic peptide-α 1 on intestinal tuberculosis

作　　者：王涛[1] 王仲元[1] 贺路星[1] 

机构地区：[1]解放军309医院结核病研究所,北京100091

出　　处：《西南国防医药》2015年第7期709-711,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的 观察抗结核2SHR/6HR化疗方案联合胸腺肽-α1治疗肠结核的临床疗效及安全性。方法 将2010年3月~2013年6月我院门诊接治的120例肠结核患者按随机数字表法分为两组,各60例,两组均给予我院针对肠结核患者的常规治疗措施,同时均实施＂2SHR/6HR＂抗结核方案;在此基础上,研究组加用胸腺肽-α1,用药16 w后,对两组治疗效果及外周血T淋巴细胞亚群（CD3^＋、CD4^＋、CD8^＋）及NK细胞水平进行比较。结果 治疗6 w后,研究组治疗总有效率达到91.67%,对照组为78.33%,组间比较有显著性差异（P〈0.05）;研究组CD3^＋、CD4^＋、CD8^＋、CD4^＋/CD8^＋及NK细胞表达情况均明显优于对照组（P〈0.05）;两组均未见明显药物不良反应。结论 抗结核2SHR/6HR化疗方案联合胸腺肽-α1治疗肠结核疗效显著,能够有效改善患者机体免疫功能,值得在临床推广应用。Objective To observe the clinical curative effects of antituberculosis 2SHR/6HR chemotherapy combined with thymic peptide-α1 on intestinal tuberculosis and its safety. Methods 120 patients with intestinal tuberculosis who received the treatment in our out-patient clinic between March 2010 and June 2013 were randomly divided into two groups with 60 cases in each group. Both groups received the routine treatment. At the same time, they received the antituberculosis 2SHR/6HR chemotherapy. Based on that, the research group also took thymic peptide-α1. Comparison was made in the curative effects and the levels of peripheral blood T-lymphocyte subsets （CD3^＋, CD4^＋, and CD8^＋） and NK cells between the two groups 16 weeks after the medication. Results Sixteen weeks after the treatment,the total effective rate of the research group was 91.67%, while that of the control group was 78.33%. There was a significant difference between the two groups （P 〈 0.05）. The expression of CD3^＋, CD4^＋, CD8^＋, CD4^＋/CD8^＋ and NK cells in the research group was superior to that in the control group （P 〈 0.05）. No drug adverse reaction was observed in the two groups. Conclusion Antituberculosis 2SHR/6HR chemotherapy combined with thymic peptide-α1 has significant curative effects on intestinal tuberculosis, which can effectively improve the patients＇ immunity. It is worthwhile to be clinical promoted.

关 键 词：胸腺肽-Α1 肠结核 免疫功能 

分 类 号：R524[医药卫生—内科学]