前列地尔对慢性肾功能衰竭患者微炎症状态的影响  

Effects of alprostadil on micro-inflammatory status of patients with chronic renal failure

作　　者：张晓燕[1] 

机构地区：[1]四川省资中县人民医院肾内科,四川资中641200

出　　处：《西南国防医药》2015年第7期716-719,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨前列地尔对慢性肾功能衰竭患者微炎症状态及水通道蛋白2（AQP2）产生的影响。方法 将2012年1月~2014年6月治疗的慢性肾功能衰竭患者98例,随机分成对照组与观察组,各49例。对照组接受慢性肾功能衰竭的常规治疗,观察组给予常规治疗联合前列地尔治疗。结果 治疗后,观察组的血β2-微球蛋白（β2-MG）、尿β2-MG、血尿素氮（BUN）、血肌酐（CREA）、核因子活化B细胞κ轻链增强子（NF-κB）、白介素6（IL-6）及水通道蛋白2水平均明显低于对照组,而血红蛋白（HGB）水平则明显高于对照组（P〈0.01）;观察组的治疗总有效率（87.76%）明显高于对照组（71.43%）（P〈0.05）。结论 前列地尔用于治疗慢性肾功能衰竭疗效确切,可显著改善患者的肾功能,减轻炎症反应,并纠正水代谢紊乱。Objective To discuss of the effects of alprostadil on the micro-inflammatory status and aquaporin protein 2 （AQP2） of patients with chronic renal failure. Methods 98 patients with chronic renal failure who received the treatment between January 2012 and June 2014 were randomly divided into control and observation groups with 49 ones in each group. The control group received the conventional treatment on chronic renal failure. The observation group received the conventional treatment combined with alprostadil. Results After the treatment, the serum β2-MG, urine β2-MG, blood urea nitrogen（BUN）, serum creatinine（CREA）, NF-κB, interleukin 6 （IL-6）, and AQP2 levels of the observation group were obviously lower than those of the control group, while its level of HGB was obviously higher than that of the control group （all P 〈 0.01）. The total effective rate of the observation group （87.76%） was significantly higher than that of the control group （71.43%） （P 〈 0.05）. Conclusion Alprostadil has certain curative effects on chronic renal failure. It can significantly improve the patients＇ renal function, reduce inflammation, and correct the disorder of water metabolism.

关 键 词：肾功能衰竭 前列地尔 微炎症状态 水通道蛋白2 

分 类 号：R692.5[医药卫生—泌尿科学]