超声造影对乳腺癌患者新辅助化疗效果的评估价值  

Value of ultrasonic contrast in evaluation of neoadjuvant chemotherapeutic effects on patients with breast cancer

作　　者：李玲[1] 李玉明[2] 李华斌[1] 卢蕊[1] 郭冀梅[1] 陈俐利[1] 

机构地区：[1]成都军区机关医院特检科,成都610011 [2]成都军区药材库

出　　处：《西南国防医药》2015年第7期737-740,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的 研究超声造影对乳腺癌患者新辅助化疗效果的评估价值,与核磁共振灌注成像和彩色多普勒超声做比较。方法 选取2011年1月~2014年11月在我院接受新辅助化疗的乳腺癌患者60例,在化疗前后均进行超声造影、核磁共振灌注成像和彩色多普勒超声检查,将检查结果与病理诊断结果做比较,评估3种诊断方式的准确性。结果 60例乳腺癌患者经新辅助化疗后,病理诊断结果为完全缓解16例,部分缓解29例,无缓解15例;超声造影检查结果为完全缓解25例,部分缓解23例,无缓解12例;核磁共振灌注成像检查结果为完全缓解22例,部分缓解25例,无缓解13例;彩色多普勒超声检查结果为完全缓解27例,部分缓解23例,无缓解10例。三者与病理诊断结果比较,Mc Nemar-Bowker检验结果显示,P值均〉0.05,显示三者的诊断结果与病理检查结果均有一定的相关性;Kappa检验结果显示,核磁共振灌注成像结果与病理检查结果一致性最好。结论 超声造影、核磁共振灌注成像和彩色多普勒超声对乳腺癌患者新辅助化疗效果均有一定的评估价值,核磁共振灌注成像与病理诊断结果的一致性最好,可作为首选,超声造影可作为疗效评价的辅助手段。Objective To investigate the value of ultrasonic contrast in the evaluation of neoadjuvant chemotherapeutic effects on patients with breast cancer, and to compare that treatment with nuclear magnetic resonance perfusion imaging and color Doppler ultrasound. Methods Sixty cases of breast cancer that received the neoadjuvant chemotherapy between January 2011 and November 2014 were treated by ultrasonic contrast, magnetic resonance perfusion imaging, and color Doppler ultrasound examination before and after the chemotherapy. Comparison was made between the examination results and the pathological diagnosis. Evaluation was made in the the accuracy of the three diagnostic methods. Results After the neoadjuvant chemotherapy, the ultrasonic contrast showed complete remission in 16 cases, partial remission in 23 ones, no remission in 12 ones; magnetic resonance perfusion imaging showed complete remission in 22 cases, partial remission in 25 ones, and no remission in 13 ones; the color Doppler ultrasound showed complete remission in 27 cases, partial remission in 23 ones, and no remission in 10 ones. McNemar-Bowker test results showed that P values were all 〉0.05, which indicated that there was a certain correlation between the diagnostics results by the three methods and the pathologic examination results. Kappa test results indicated that the consistency of nuclear magnetic resonance perfusion imaging with the pathologic results was the best. Conclusioon Ultrasonic contrast, magnetic resonance perfusion imaging and color Doppler ultrasound all have certain value in the evaluation of neoadjuvant chemotherapeutic effects on patients with breast cancer. Nuclear magnetic resonance perfusion imaging has the best consistency with the pathological diagnosis and can be used as the first choice. Ultrasonic contrast can be used as the auxiliary method for the therapeutic evaluation.

关 键 词：超声造影 核磁共振灌注成像 彩色多普勒超声 乳腺癌 新辅助化疗 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]