干扰素治疗慢性乙型肝炎疗效预测因素的研究进展  

Research progress on predictors of interferon treatment in patients with chronic hepatitis B

作　　者：王坤[1] 朱传龙[2] 

机构地区：[1]安徽医科大学附属安徽省立医院感染病科,合肥230001 [2]南京医科大学第一附属医院感染病科,南京210029

出　　处：《临床与病理杂志》2015年第6期1157-1163,共7页Journal of Clinical and Pathological Research

基　　金：国家自然科学基金资助项目(81271713);安徽省第五批优秀青年科技基金滚动支持项目(1308085JGD09)~~

摘　　要：对于慢性乙型肝炎患者,干扰素-α常作为首选抗乙肝病毒的药物之一,具有疗程有限、疗效持久的优点,但因其毒副作用多且抗病毒效率低等缺点限制了干扰素的临床应用。因此如何在抗病毒前预测干扰素-α抗病毒疗效至关重要。本文就影响干扰素-α疗效的各种因素进行简要综述,为临床医生选择干扰素-α治疗慢性乙型肝炎患者提供参考。Interferon-alpha （IFN-α） remains as one of the first-line drugs used in chronic hepatitis B treatment. IFN-a has several advantages, such as finite course of therapy and long-term benefit. Howeverj clinical application of IFN-α is still limited due to its side effect and inefficient antiviral ability. Therefore, it is very important for physicians to learn how to predict the efficacy of IFN-α treatment in patients with chronic hepatitis B. In this review, we focus on some various factors which can affect the efficacy oflFN-a treatment, hoping can provide reference for the clinicians.

关 键 词：干扰素 慢性乙型肝炎 疗效 

分 类 号：R512.62[医药卫生—内科学]