庆大霉素与糖皮质激素治疗梅尼埃病效果的Meta分析  

Effect of gentamicin and glucocorticoid on meniere′s disease:a Meta analysis

作　　者：龙宇[1] 江洪[1] 陈丽鸿[1] 赵辉[1] 

机构地区：[1]重庆医科大学附属永川医院耳鼻咽喉-头颈外科学,重庆永川402160

出　　处：《重庆医学》2015年第20期2805-2808,共4页Chongqing medicine

摘　　要：目的比较庆大霉素(IG)与糖皮质激素(GC)治疗梅尼埃病的疗效。方法计算机检索PubMed、OVID、Cochrane Library、MEDLINE、CNKI、万方等数据库,检索时间为建库至2014年6月;手工检索相关杂志纸质版。对纳入的文献进行评价,用RevMan 5.2软件进行统计分析。结果共纳入7篇随机对照试验。Meta分析结果显示:在控制眩晕方面,IG优于GC,差异有统计学意义(P<0.05);在听力改善方面,GC与IG的差异无统计学意义(P>0.05)。结论 GC治疗梅尼埃病对眩晕改善效果不如IG;GC与IG在听力改善方面无明显差异。Objective To systematically evaluate the efficacy of gentamicin（IG） versus Glucocorticoids（GC） in treatment of Meniere disease. Methods Literature was retrieved online in PubMed, OVID, Cochrane Library, MEDLINE, CNKI and Wanfang database up to June 2014. Relevant magazines were retrieved manually. The included studies was assessed and Meta analysis was performed with RevMan 5.2 software. Results Seven randomized controlled trials （RCTs） were finally included. Meta analyses showed that;in terms of improvement of vertigo, IG group was more effective than GC group, the difference was statistically signifi- cant （P〈0.05） ;in terms of hearing improvement, there was no significant difference between GC group and IG group （P〉0.05）. Conclusion In terms of improvement of vertigo,the effect of GC group is inferior to IG group;in terms of hearing improvement, there was no significant difference between GC group and IG group.

关 键 词：庆大霉素类 糖皮质激素类 梅尼埃病 系统评价 

分 类 号：R764.33[医药卫生—耳鼻咽喉科]