经前烦躁症肝气郁证发病机制初探  

Study on the Pathogenesis of Premerstrual Dysphoric Disorder Liver-qi Stagnation Syndrome

作　　者：张震[1] 高冬梅[1] 乔明琦[1] 

机构地区：[1]山东中医药大学,济南250355

出　　处：《中国中医基础医学杂志》2015年第6期768-771,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家重点基础研究发展计划(973计划)-肝藏象生理病理及情志致病机理研究(2011CB505102)

摘　　要：通过对近几年经前烦躁症(PMDD)肝气郁证发病机制的初步探究发现,PMDD肝气郁证关键发病机制在于雌、孕激素分泌异常及其受体(ERα和ERβ)表达异常升高,单胺类神经递质5-HT、DA、E含量升高,NE含量降低,γ-氨基丁酸(GABA)及其受体水平调节紊乱。PMDD肝气郁证与心理和社会影响因素、微量元素缺陷以及其他方面因素关系密切。Through the preliminary inquiry of pathogenesis of PMDD Liver-qi stagnation syndrome recent years it is found that the key pathogenesis of PMDD liver-qi stagnation syndrome is： female,progesterone secretion abnormally and its receptor（ ERα and ERβ） abnormally increased; monoamine neurotrans mitter 5-HT、DA、E content increased,NE content decreased,gamma-aminobutyric acid（ GABA） and receptor level adj-ustment disorder; A close relationship with psychological and social factors,trace element deficiency and other aspects.

关 键 词：经前烦躁症 肝气郁证 四氢孕酮 五羟色胺 Γ-氨基丁酸 

分 类 号：R271.111[医药卫生—中医妇科学]