中医药防治肺纤维化作用机制研究进展  

Research Progress of Mechanism of Traditional Chinese Medicine in Prevention and Treatment of Pulmonary Fibrosis

作　　者：渠景连[1] 龚婕宁[1] 

机构地区：[1]南京中医药大学基础医学院,南京210023

出　　处：《中国中医基础医学杂志》2015年第6期772-775,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目(81373603)-基于Notch信号通路及其表观遗传改变探讨养肺活血方防治肺纤维化的作用机制

摘　　要：肺纤维化是多种因素引起的弥漫性肺间质疾病,以弥漫性肺泡炎和肺泡结构紊乱最终导致肺间质纤维化为特征。本病临床缺乏特效药物,中医药在防治肺纤维化方面优势渐显,作用机制研究也不断深入。故通过归纳、总结近年来的相关文献,从减轻炎症反应、改善细胞外基质代谢、干预细胞凋亡、调节微血管新生、纠正氧化/抗氧化失衡、调节免疫功能、减轻内质网应激7个方面阐述了中医药防治肺纤维化的作用机制研究进展,可为临床中医药有效防治肺纤维化提供实验室依据。Pulmonary fibrosis is a kind of diffuse interstitial lung disease caused by a variety of factors,characterized by diffuse alveolitis and alveolar structural destruction which finally leading to fibrosis. This disease was lack of specific medicine in clinic,while the advantages of traditional chinese medicine in prevention and treatment of pulmonary fibrosis are increasingly significant,and the studies on its mechanism are in deepening. In this article,through induction and summary of related literature in recent years,expounded the research progress of mechanism of traditional chinese medicine in prevention and treatment of pulmonary fibrosis from the following seven aspects： anti-inflammation,improving the metabolism of extracellular matrixc,intervention apoptosis,regulating angiogenesis,correcting the imbalance of oxidation and antioxidant,regulating immunological function and alleviating endoplasmic reticulum stress,in order to provide laboratory basis for prevention and treatment of pulmonary fibrosis with traditional chinese medicine in clinic.

关 键 词：中医药 肺纤维化 作用机制 

分 类 号：R563.13[医药卫生—呼吸系统]