脐疗法对脾虚型肠易激综合征尿液代谢组学影响  

Effects of Herbal Medicine of Umbilical Moxibustion on Urine Metabolism with Patients with Irritable Bowel Syndrome(IBS)of Spleen Deficiency Type

作　　者：张晓宁[1] 马玉侠[1] 

机构地区：[1]山东中医药大学针灸推拿学院

出　　处：《四川中医》2015年第6期59-61,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(编号:2007CB512703)

摘　　要：目的:采用隔药灸脐和隔淀粉灸脐治疗脾虚型肠易激综合征,从代谢组学角度研究隔药灸脐法治疗脾虚型肠易激综合征的深层微观机制。方法:选取脾虚型肠易激综合征患者24例,随机分为隔药灸脐组和隔淀粉灸脐组,每组12例,对治疗前、后该组患者尿样血浆进行处理,寻找有贡献的潜在代谢物质及相关代谢通路。结果:隔药灸脐法和隔淀粉灸脐法治疗肠易激综合征的代谢产物谱均发生了显著性变化,其中变化较为显著的是氨基酸、儿茶酚胺类及胆汁酸代谢物,涉及到体内的氨基酸代谢、神经递质代谢。隔药灸脐组还涉及内源性大麻素代谢,隔淀粉灸脐组还涉及抗胆碱酯酶物质代谢。结论:隔药灸脐法可显著抑制肠易激综合征患者的内脏高敏性,改善肠道神经、免疫、内分泌网络失调状况,较于隔淀粉灸脐组其产生可缓解肠易激患者临床症状的代谢产物和代谢途径更多且更直接,因而隔药灸脐法的药物在治疗肠易激综合征的过程中起到了确切有效的作用。Objective：The study tries to investigate the metabolic level differences between medicine-separated umbilical moxibustion and starch-separated umbilical moxibustion.Trying to find out potential biological markers and derive related metabolic pathway of umbilical moxibustion on irritable bowel syndrome of spleen deficiency.In order to determine the efficacy of umbilical moxibustion.Methods：24irritable bowel syndrome of spleen deficiency patients were randomly divided into two groups.Dealing with this group of patients urine and plasma samples before and after treatment.According to the Simca-P 11.5software package processing data,looked for the contribution of the metabolite fractions and search of related metabolic pathway by HMDB,KEGG.Results：Medicine-separated umbilical moxibustion and starch-separated umbilical moxibustion had undergone significant changes.Changes in more significant were amino acids,catecholamines and bile acids,these metabolites involved in amino acid metabolism and neurotransmitter metabolism.Medicine-separated umbilical moxibustion also involves endogenous cannabinoids metabolism.Starchseparated umbilical moxibustion also involved arachidonic acid metabolism.Conclusion：The umbilical moxibustion can significantly inhibit the irritable bowel patients with visceral hypersensitivity,improve intestinal nervous immune,endocrine disorder state,alleviate clinical symptoms and improve the diarrhea type irritable bowel patients＇ life quality.

关 键 词：隔药灸脐法 神阙 脾虚型肠易激综合征 代谢组学 

分 类 号：R285.5[医药卫生—中药学]