肺间质纤维化继发真菌感染的菌群分布及耐药分析  

Fungal distribution and drug resistance of pulmonary interstitial fibrosis accompanied by pulmonary fungal infection

作　　者：买佳[1] 王静[1] 

机构地区：[1]郑州大学第一附属医院呼吸与危重症医学科,河南郑州450052

出　　处：《河南医学研究》2015年第1期20-22,共3页Henan Medical Research

基　　金：河南省重点科技攻关项目(编号:2011020002)

摘　　要：目的分析肺间质纤维化继发真菌感染的菌群分布及耐药情况。方法选取郑州大学第一附属医院呼吸科收治的45例肺间质纤维化继发性真菌感染患者,对真菌菌群分布、药敏试验结果进行分析。结果肺间质纤维化继发真菌感染菌群分布情况为白色念珠菌24株,占53.33%;光滑念珠菌10株,占22.22%;热带念珠菌6株,占13.33%;克柔念珠菌2株,占4.44%;近平滑念珠菌1株,占2.22%;曲霉菌2株,占4.44%。对氟康唑、伊曲康唑、伏立康唑、两性霉素B、5-氟胞嘧啶耐药率分别为17.78%、26.67%、8.89%、0.00%、0.00%。结论肺间质纤维化继发真菌感染以白色念珠菌最常见,对伊曲康唑耐药性较强。应重视肺间质纤维化继发真菌感染的诊断及合理用药。Objective To investigate the fungal distribution and drug resistance of pulmonary interstitial fibrosis accompanied by pulmonary fungal infection. Methods 45 cases of pulmonary interstitial fibrosis accompanied by pulmonary fungal infection treated in the First Affiliated Hospital of Zheng Zhou University were selected. The fungal distribution and drug resistance was analyzed.Results There were 24 strains of Candida albicans,accounted for53. 33%; 10 strains of Candida glabrata,accounted for 22. 22%; 6 strains,accounted for 13. 33%; 2 strains of Candida krusei,accounted for 4. 44%. Fluconazole,itraconazole,amphotericin B,Fushita Yasu,5-fluorocytosine resistance rates were17. 78%,26. 67%,8. 89%,0. 00%,0. 00% respectively. Conclusion Candida albicans was the most common cause of pulmonary interstitial fibrosis accompanied by pulmonary fungal infection with strong resistance to itraconazole. The diagnosis and rational use of drugs for pulmonary interstitial fibrosis accompanied by pulmonary fungal infection should be paid more attentions.

关 键 词：肺间质纤维化 真菌感染 菌群分布 耐药 

分 类 号：R563.9[医药卫生—呼吸系统]