Scx(Scleraxis)在肌腱组织工程中的研究进展  

Research progress of Scx( Scleraxis) in tendon tissue engineering

作　　者：王强[1] 曲彦隆[1] 

机构地区：[1]哈尔滨医科大学附属第一临床医学院,黑龙江哈尔滨150001

出　　处：《中国矫形外科杂志》2015年第12期1096-1099,共4页Orthopedic Journal of China

摘　　要：肌腱损伤是临床常见疾病,目前尚无十分良好的治疗方法,应用组织工程化肌腱治疗肌腱损伤具有广阔的前景。了解肌腱的发育成熟过程对于构建功能良好的组织工程化肌腱是相当重要的。Scx(Scleraxis)在肌腱发育成熟中起了非常重要的作用,是肌腱和韧带相对特异分子标志。本文就Scx的分子结构、在肌腱发育成熟中的作用及其调控机制进行综述。Tendon injury is a common clinical disease,but there is no very ideal therapy of it at present. Application of tissue engineered tendon to treat tendon injury has broad prospects. It＇s important to understand the tendon maturity to build well-behaved tissue engineered tendon. Scleraxis（ Scx）,a relatively specific molecular marker in tendon and ligament,plays a very important role in tendon maturity. In this paper,we reviewed the molecular structure of Scx,as well as its function,regulatory mechanism,and application progress in tendon maturity.

关 键 词：SCLERAXIS 肌腱 组织工程 细胞因子 

分 类 号：R318.08[医药卫生—生物医学工程]