A Retrospective Study of Pulmonary Actinomycosis in a Single Institution in China  

作　　者：Xue-Feng Sun Peng Wang Hong-Rui Liu Ju-Hong Shi 

机构地区：[1]Department of Respiratory Medicine, Peking Union Medical College Hospital, Beijing 100730, China [2]Department of Clinical Microbiology, Peking Union Medical College Hospital, Beijing 100730, China [3]Department of Pathology, Peking Union Medical College Hospital, Beijing 100730, China

出　　处：《Chinese Medical Journal》2015年第12期1607-1610,共4页中华医学杂志（英文版）

摘　　要：Background：Actinomycosis is a rare indolent infectious disease caused by Actinomyces.Although pulmonary actinomycosis is thought to be more prevalent in developing countries,data from developing countries are scanty.This study was to reveal the current situation of pulmonary actinomycosis in developing countries and the difference from that in developed countries.Methods：Patients fulfilling the inclusion criteria for pulmonary actinomycosis from Peking Union Medical College Hospital in China between January 2003 and December 2014 were retrospectively analyzed.Baseline characteristics,clinical symptoms,underlying diseases,diagnostic methods,pulmonary function test results,chest computed tomography （CT） tests,fluoro-2-deoxy-D-glucose positron emission tomography （FDG-PET） tests,initial diagnosis,treatment and prognosis were retrieved from medical records and analyzed.Results：Twenty-six patients were included in this study （mean age 52.0 ＋ 13.1 years）.The ratio of male to female was 1.17：1.Most common clinical symptoms were cough （15/26）,sputum （12/26） and hemoptysis （12/26）.Chest CT findings presented as masses （13/26）,nodules （10/26） and infiltrates （3/26）.FDG-PET had an increased standardized uptake value and 4/6 patients were misdiagnosed as malignancy.Many kinds of antibiotics were used in the treatment of pulmonary actonomycosis and all got favorable results.Five patients receiving complete resection of the lesion were cured without postoperative use of antibiotic.Conclusions：Pulmonary actinomycosis is a rare disease even in developing countries,and both misdiagnosis and missed diagnosis are common.FDG-PET seems useless in the differential diagnosis,and complete resection of the pulmonary lesion without postoperative antibiotic therapy might be enough to achieve cure.Background：Actinomycosis is a rare indolent infectious disease caused by Actinomyces.Although pulmonary actinomycosis is thought to be more prevalent in developing countries,data from developing countries are scanty.This study was to reveal the current situation of pulmonary actinomycosis in developing countries and the difference from that in developed countries.Methods：Patients fulfilling the inclusion criteria for pulmonary actinomycosis from Peking Union Medical College Hospital in China between January 2003 and December 2014 were retrospectively analyzed.Baseline characteristics,clinical symptoms,underlying diseases,diagnostic methods,pulmonary function test results,chest computed tomography （CT） tests,fluoro-2-deoxy-D-glucose positron emission tomography （FDG-PET） tests,initial diagnosis,treatment and prognosis were retrieved from medical records and analyzed.Results：Twenty-six patients were included in this study （mean age 52.0 ＋ 13.1 years）.The ratio of male to female was 1.17：1.Most common clinical symptoms were cough （15/26）,sputum （12/26） and hemoptysis （12/26）.Chest CT findings presented as masses （13/26）,nodules （10/26） and infiltrates （3/26）.FDG-PET had an increased standardized uptake value and 4/6 patients were misdiagnosed as malignancy.Many kinds of antibiotics were used in the treatment of pulmonary actonomycosis and all got favorable results.Five patients receiving complete resection of the lesion were cured without postoperative use of antibiotic.Conclusions：Pulmonary actinomycosis is a rare disease even in developing countries,and both misdiagnosis and missed diagnosis are common.FDG-PET seems useless in the differential diagnosis,and complete resection of the pulmonary lesion without postoperative antibiotic therapy might be enough to achieve cure.

关 键 词：ACTINOMYCOSIS Computed Tomography LUNG MISDIAGNOSIS Treatment 

分 类 号：S858.23[农业科学—临床兽医学] TL411.4[农业科学—兽医学]