原发性肝细胞癌患者血清中VCAM-1的表达及临床意义  

The level of serum VCAM-1 in patients with primar y hepatocellular carcinoma and its clinical signii cance

作　　者：葛超[1] 李红[1] 屠红[1] 陈陶阳[2] 谢海洋[3] 崔英[4] 李锦军[1] 

机构地区：[1]上海交通大学医学院附属仁济医院上海市肿瘤研究所癌基因与相关基因国家重点实验室,上海200032 [2]启东肝癌防治研究所,江苏启东226200 [3]浙江大学医学院第一附属医院肝胆胰外科,浙江杭州310003 [4]广西肿瘤防治研究所,广西南宁530021

出　　处：《肿瘤》2015年第6期646-652,共7页Tumor

基　　金：国家自然科学基金资助项目(编号:81201623;81372192);上海市教委创新重点项目(编号:13ZZ082)~~

摘　　要：目的 :检测原发性肝细胞癌患者血清中血管细胞黏附分子-1(vascular cell adhesion molecule-1,VCAM-1)的表达水平,并探讨其临床意义。方法:采用酶联免疫吸附测定法(enzyme-linked immunosorbent assay,ELISA)检测414例原发性肝细胞癌患者、120例肝炎患者和92例健康人血清中VCAM-1的表达水平,分析血清中VCAM-1的水平与肝细胞癌患者临床病理特征的相关性及与患者生存期的关系。结果 :肝细胞癌患者血清中VCAM-1的表达水平明显高于肝炎患者及健康对照组(P<0.000 1),且与血清中甲胎蛋白(alpha-fetoprotein,AFP)的表达水平密切相关(P=0.021)。Kaplan–Meier分析结果表明,VCAM-1表达水平高的肝细胞癌患者生存期短(P=0.023)。结论 :血清中VCAM-1的表达水平可以作为原发性肝细胞癌诊断和预后的潜在标志物。Objective： To examine the level of serum vascular cell adhesion molecule-1（VCAM-1） in patients with primary hepatocellular carcinoma（HCC）, and to explore its clinical significance.Methods： Serum specimens from 414 HCC patients were included in this study, in addition to samples from 92 healthy individuals and 120 patients with chronic hepatitis B virus（HBV） infection. Serum VCAM-1 levels were detected using an enzyme-linked immunosorbent assay（ELISA）, and the correlation between VCAM-1 levels and clinical features was evaluated.Results： The serum VCAM-1 level was significantly higher in HCC patients than in healthy individuals or patients with chronic HBV infection（HBV carriers）（P 〈 0.000 1）. Moreover, the serum VCAM-1 level was correlated with alpha-fetoprotein（AFP） levels（P = 0.021） but not with gender, age, tumor size, histological grade, HBV infection, intrahepatic metastasis or cirrhosis in HCC patients. Kaplan-Meier analysis indicated that higher VCAM-1 level was associated with shorter survival in HCC patients（P = 0.023）.Conclusion： These results suggest that the serum level of VCAM-1 may serve as a potential diagnostic and prognostic biomarker for primary HCC patients.

关 键 词：癌 肝细胞 血管细胞黏附分子-1 血清学试验 预后 

分 类 号：R735.7[医药卫生—肿瘤]