短期吸食海洛因和冰毒者戒断后静息态低频振幅改变的研究  

The study of low frequency fluctuation in the resting state between short-term heroin and methamphetamine abusers after withdrawal

作　　者：于洋[1,2] 娄明武[2] 鲁琳[2] 梁文斌[2] 申云霞[2] 

机构地区：[1]遵义医学院珠海校区,广东珠海519041 [2]深圳市龙岗中心医院医学影像科

出　　处：《实用放射学杂志》2015年第6期887-890,共4页Journal of Practical Radiology

基　　金：国家自然科学基金项目（81471661）;深圳市科技创新委员会项目（JCY20130329113350856）;深圳市龙岗区科技创新局项目（YS2013095）.

摘　　要：目的：探讨短期吸食海洛因和冰毒者戒断后静息态下脑低频振幅（ALFF）的差异。方法对16例男性短期吸食海洛因者和14例男性短期吸食冰毒者进行静息态功能磁共振成像（fMRI）扫描，将获得的脑功能数据通过预处理软件获得 ALFF 图像，观察2组间图像的差异。阈值设为0.05。结果与冰毒组比较，海洛因组 ALFF 升高的脑区为左侧舌回，左侧小脑扁桃体；ALFF 减低的脑区为左侧脑干，中脑，左侧小脑蚓部。结论短期海洛因吸食者和冰毒吸食者戒断后脑功能存在差异，差异主要位于认知和情感系统。Objective To investigate the differences of low frequency fluctuation （ALFF）in the resting state between short-term heroin and methamphetamine abusers after withdrawal.Methods Sixteen male short-term heroin abusers and fourteen male short-term methamphetamine abusers were performed the functional magnetic resonance imaging （fMRI）.The differences of ALFF be-tween the two groups were performed with preprocessing softwares.Threshold was set to 0.05.Results Compared with metham-phetamine-dependent patients,heroin-dependent patients showed increased ALFF in the left side of the lingual gyrus and the left ton-sil of cerebellum and decreased ALFF in the left side of the brain stem,midbrain and the left side of the cerebellar vermis.Conclusion There are differences between the short-term heroin and methamphetamine abusers in the function of the brain,mainly involving the brain regions associating with cognition and affection.

关 键 词：海洛因 冰毒 低频振幅 静息态功能磁共振成像 

分 类 号：R996[医药卫生—毒理学] R445.2[医药卫生—药学]