三磷酸腺苷结合盒亚家族G超家族第二个成员（ABCG2）基因rs2231142多态性与痛风发病风险的Meta分析  

The ABCG2 gene rs2231142 polymorphism contributes to the increased risk for gout：a meta-analysis

作　　者：邱亚[1] 柳华[1] 周京国[2] 青玉凤[2] 赵明才[1] 谢文光[1] 党万太[1] 

机构地区：[1]川北医学院附属医院风湿免疫所,南充637000 [2]川北医学院风湿免疫科

出　　处：《中华风湿病学杂志》2015年第6期384-388,共5页Chinese Journal of Rheumatology

摘　　要：目的：运用Meta分析方法探讨三磷酸腺苷结合盒亚家族G超家族第2个成员（ABCG2）基因rs2231142多态性与痛风发病的相关性。方法全面检索中外文数据库，合格研究的质量采用NOS量表评估。使用随机或固定效应模型计算比值比（OR），评估异质性和发表偏倚，对人种和性别进行了亚组分析。结果10个研究包括3478例痛风患者纳入Meta分析。rs2231142 A等位基因[OR=2.03，95%CI （1.77，2.34），P〈0.01]和AA纯合子[OR=3.01，95%CI（2.34，3.88），P〈0.01]携带者痛风发病风险更高，亚组分析结论类似。结论 ABCG2基因rs2231142多态性与痛风发病风险相关，该结论需扩大样本在不同人种人群中进一步验证。Objective This study is aimed to evaluate the association between the ABCG2 gene rs2231142 variant and gout using meta-analysis. Methods Related studies were identified by searching extensively in Chinese and foreign language databases such as Pubmed, EMBASE, Cochrane Library, CBMdisc databases and so on. The quality of included studies was assessed by using the Newcastle-Ottawa Scale （NOS）. The odds ratio （OR） was calculated using a random-effects or fixed-effects model. A Q statistic was used to evaluate the heterogeneity, and Eggerˊs test and funnel plot were used to assess publication bias. Sub-group analyses on ethnicities and sex were also performed. Results A total of 10 studies, including 3 478 gout patients and 10,089 controls from 6 countries or regions, were included and identified for the current metaan-alysis. It was found that the A allele or AA genotype of the ABCG2 rs2231142 polymorphism had an increased risk for gout in the general population [A allele： OR=2.03, 95%CI （1.77, 2.34）, P〈0.01 and AA genotype： OR=3.01, 95%CI （2.34, 3.88）, P〈0.01, respectively]. Similar results were found in sub-group analyses of different gender and races. Conclusion Existing evidence indicate that rs2231142 polymorphism （the A allele and AA genotype） is associated with increased risk of gout.

关 键 词：痛风 META分析 ABCG2基因 rs2231142 单核苷酸多态性 

分 类 号：R589.7[医药卫生—内分泌]