CIDEB、CIDEC 基因单倍型及单倍型交互作用与肥胖的关系  

The main effect and interaction between haplotypes of CIDEB and CIDEC to obesity

作　　者：平智广[1] 刘莉[2] 詹芳芳[1] 戚敏杰[1] 乐晓萍[2] 

机构地区：[1]郑州大学公共卫生学院,450001 [2]郑州大学基础医学院

出　　处：《中华内分泌代谢杂志》2015年第6期518-521,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金（81001280,81202277）;河南省科技攻关项目（112102310198）

摘　　要：选取528名无关研究对象,男性198人,女性330人,平均年龄（52.2±13.4）岁,依体重指数分为正常体重组253人和超重肥胖组275人。检测 CIDEB 和 CIDEC 基因的10个 SNPs,采用 SHEsis 分析基因的单倍型。按加性遗传模式对各位点与肥胖的关系进行 logistic 回归,分析两种基因的单倍型致肥胖的主效应与交互作用。 CIDEB 基因的 rs2144493位点可能与肥胖有关,C 为保护性等位基因,OR（95% CI）为0.722（0.525~0.992）。 CIDEB 基因 CCTT 单倍型携带者和 CIDEC 基因 GCG 单倍型携带者可能更易患超重肥胖。两个基因单倍型之间存在交互作用。 CIDEB、CIDEC 基因单倍型在致肥胖方面可能存在独立以及交互作用。[Summary] A selection of 528 unrelated subjects were enrolled（198 males, 330 females） with the mean age of（52. 23 ± 13. 41） years old. According to body mass index, 253 persons belonged to the normal weight group and 275 persons overweight/ obesity group. A total of 10 SNPs in CIDEB and CIDEC genes were detected. SHEsis online were used to get the haplotypes of these two genes. The relationship between above SNPs and obesity were analyzed under additive inheritance pattern. The main effects and interaction on obesity induced by two genes’ haplotypes were analyzed by logistic regression. rs2144493 in CIDEB gene was associated with obesity, C was a protective alleles, OR （95% CI） equals 0. 722（0. 525-0. 992）. CCTT haplotype of CIDEB gene carriers and GCG haplotype of CIDEC gene carriers were more prone to obesity or overweight, there was an interaction between the haplotypes of 2 genes. CIDEB, CIDEC haplotypes may play independent and interactive roles in causing obesity.

关 键 词：CIDE 基因 单倍型 肥胖 交互作用 

分 类 号：R589.2[医药卫生—内分泌]