黄酮类化合物在防治神经退行性疾病中作用的研究进展  

Progress in prevention and treatment of neurodegenerative diseases with flavonoids

作　　者：曹秦[1] 吴辉[1] 张蓓蓓[1] 吴晓俊[1] 

机构地区：[1]上海中医药大学中药研究所中药标准化教育部重点实验室上海市复方中药重点实验室,上海201203

出　　处：《中国药理学与毒理学杂志》2015年第3期457-463,共7页Chinese Journal of Pharmacology and Toxicology

基　　金：上海高校特聘教授(东方学者)岗位计划资助(2013-59);教育部高等学校博士学科点专项科研基金优先发展领域项目(20123107130002);上海教委科研创新重点项目(13ZZ099)~~

摘　　要：帕金森病、阿尔茨海默病及亨廷顿病等一系列神经退行性疾病的发病因素很多,其中包括神经炎症、内源性抗氧化剂缺失、谷氨酸兴奋性神经毒性损伤以及铁离子代谢异常等。研究表明,黄酮类化合物对神经退行性疾病的临床防治具有一定的疗效。黄酮类化合物可抑制神经炎症、抗氧化应激、抗细胞凋亡、抗谷氨酸神经毒性并调节铁代谢平衡,从而减缓神经细胞损伤并改善学习记忆和脑血管功能。Studies of neurodegenerative diseases, such as Parkinson disease （ PD）, Alzheimer dis- ease （AD） and Huntington disease （ HD）, so far have proved that the cause of these diseases is a complex process involving multiple factors and mechanisms, including neuroinflammation, lack of endog- enous antioxidants, glutamate excitotoxicity, and abnormal metabolism of iron. Numerous studies showed that treatment with flavonoids is effective for neurodegenerative diseases. This review summarizes the mechanisms by which flavonoids slow down neuronal damage and improve memory, cognitive per- formance and cerebrovascular function by anti-neuroinflammation, anti-oxidative stress, anti-apoptosis, anti-glutamate neurotoxicity and modulation of iron homeostasis.

关 键 词：神经退行性疾病 黄酮 炎症 神经保护药 学习 记忆 认知 

分 类 号：R277.7[医药卫生—中医学]