基质金属蛋白酶3在活髓保存治疗中的研究进展  

Research progress of matrix metalloproteinase 3 in vital pulp conservation treatment

作　　者：李雯[1] 尹硕[2] 刘继明[3] 王玉峰[2] 马珊珊[4] 朱红华[5] 罗莹[6] 张颖丽[1] 

机构地区：[1]吉林大学口腔医院牙体牙髓病科,吉林长春130021 [2]吉林大学口腔医院修复科,吉林长春130021 [3]吉林大学口腔医院正畸科,吉林长春130021 [4]吉林大学口腔医院种植科,吉林长春130021 [5]吉林大学口腔医院放射科,吉林长春130021 [6]长春市中医院口腔科,吉林长春130021

出　　处：《口腔医学》2015年第6期500-503,共4页Stomatology

基　　金：吉林省科技发展计划(20130102096JC);长春市科技计划项目(12SF88)

摘　　要：牙髓组织是疏松的结缔组织,当遇到外界刺激时能够产生一系列级联反应进行自身修复。活髓的保存治疗成为牙髓生物学研究的热点,主要以氢氧化钙、MTA及复合盖髓材料盖髓剂为代表。基质金属蛋白酶3(MMP3)不仅可以降解细胞外基质成分,还与组织形态发生,损伤修复,炎症反应等过程有着密切的联系。随着对MMP3研究的不断深入,揭示出其在损伤牙髓组织中高表达,同时也促进了成牙本质细胞的增殖和分化。将MMP3制成生物活性盖髓材料覆盖于牙髓断面后发现MMP3促进了新生血管和硬组织的形成,提示MMP3可能参与了牙髓损伤后的修复过程。这就为开发新型生物活性盖髓材料提供了新思路。该文就近几年活髓保存治疗的现状及MMP3在活髓保存治疗中的研究进展做一综述。Dental pulp tissue is a loose connective tissue and can produce a series of cascade reactions to external stimulations for self repair. The conservation treatment of vital pulp is becoming a hot topicin dental pulp biology, and calcium hydroxide, MTA as well as composite pulp capping materialare the main capping agents. Matrix metalloproteinase 3 （ MMP3 ） can not only degrade extraeellu]ar matrix components but also has close relations with tissue morphogenesis,damage repair,inflammation and other processes. Researches on MMP3 have revealed its high expressionin injured pulp tissue andthat it promotes the proliferation and differentiation of odontoblasts. Covered withbioactive pulp capping material made of MMP3,the formation of hard tissues and angiogenesis was accelerated,suggesting that MMP3 may have participated in therepair of the injured pulp. This provides a new idea for the development of new bioactive pulp capping material. This paper reviewed the current situation of conservation treatment of vital pulp and the research progress of MMP 3 in the vital pulp conservation treatment.

关 键 词：牙髓修复 盖髓剂 基质金属蛋白酶3 

分 类 号：R345.9[医药卫生—基础医学]