骨髓造血干细胞的起源——血管内皮生血化?  

Origin of Hematopoietic Stem Cells in Bone Marrow——Endothelial to Hematopoietic Transition(EHT)?——Review

作　　者：王芬[1] 袁燕[1] 陈彤[1] 

机构地区：[1]复旦大学附属华山医院血液科,上海200040

出　　处：《中国实验血液学杂志》2015年第3期866-870,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金项目(31371480;81100385);国家重大研究计划(2011CB910404);上海市基础研究重点项目(13JC1406404)

摘　　要：与原始造血相比,胚胎期具有永久造血功能的造血干细胞起源于生血内皮细胞,胚胎的卵黄囊、AGM区、胎盘、胎颅、胚胎血管等,均以内皮生血化的形式进行永久造血,但是在胎肝和骨髓是否也以此方式永久造血尚不十分明确。近来的研究表明,骨髓永久造血与血管内皮细胞的联系也非常密切。本文总结了胚胎内皮生血化的相关机制,并对骨髓是否也有内皮生血化进行了讨论和综述。In contrast to primitive hematopoiesis, during embryonic definitive hematopoiesis, it has been demonstrated that multilineage hematopoietic stem/progenitor cells （HSPCs） arise from hernogenic endothelium, and the endothelial to hematopoietic transition （EHT） exists within the yolk sac, placenta, AGM, mouse head vascular and extraembryonic vessels. However, whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, including fetal liver and bone marrow, remains largely unknown. Recently, more and more researches showed that hematopoiesis within bone marrow had a close relationship with vascular endothelium development, too. This review summarizes the mechanism of EHT during embryo development, and discuss whether EHT exists in adult hematopoiesis.

关 键 词：血管内皮细胞 生血内皮细胞 造血干细胞 造血 

分 类 号：R329.21[医药卫生—人体解剖和组织胚胎学]