指骨骨密度和膝骨关节炎相关性的影像学评价  

Relationship between phalangeal bone mineral density and radiographic knee osteoarthritis

作　　者：邓桢翰[1] 曾超[1] 李宇晟[1] 杨拓[1] 李辉[1] 雷光华[1] 

机构地区：[1]中南大学湘雅医院骨科,湖南省长沙市410008

出　　处：《中国组织工程研究》2015年第20期3163-3167,共5页Chinese Journal of Tissue Engineering Research

基　　金：中南大学研究生自主创新项目(2014zzts347)~~

摘　　要：背景:骨关节炎和骨质疏松症是与人体衰老相关的两大退行性疾病,国内外针对其相关性的研究较多,但至今仍未得出统一结论。目的:通过横断面研究探讨影像学膝骨关节炎和指骨骨密度的相关性。方法:纳入2 855名研究对象,同时测量骨密度和双膝正位片,对潜在的混杂因素进行校正,应用多变量的Logistic回归分析模型来评估影像学膝骨关节炎和指骨骨密度的相关性。结果与结论:校正因素包括性别、年龄、体质量指数、吸烟、饮酒、总能量摄入量、平均钙摄入量、营养素补充剂和钙补充剂摄入量等,发现影像学膝骨关节炎和指骨骨密度呈正相关。在女性亚组中,这一相关性仍然成立,男性亚组则不具有相关性。证实在女性人群中膝骨关节炎和指骨骨密度的正相关性,提示骨密度可能为膝骨关节炎的保护因素。BACKGROUND：Osteoarthritis and osteoporosis are two aging-related degenerative diseases. There are a lot of studies on their correlation, but no consensus has been reached yet. OBJECTIVE： To examine the cross-sectional association between phalangeal bone mineral density and radiographic knee osteoarthritis. METHODS：A total of 2 855 participants were included in this study. Phalangeal bone mineral density and anteroposterior films of the bilateral knees were detected. A multivariable logistic analysis model was applied to test the relationship between phalangeal bone mineral density and radiographic knee osteoarthritis after adjusting a number of potential confounding factors. RESULTS AND CONCLUSION：A positive association was observed between phalangeal bone mineral density and radiographic knee osteoarthritis in the model that was adjusted for sex, age, bone mass index, smoking status, alcohol drinking status, total energy intake, mean calcium intake, as wel as vitamin and Ca supplementation. This association existed in the total sample and the female subgroup, but not in the male. These findings suggest a positive relationship between phalangeal bone mineral density and radiographic knee osteoarthritis in the female subgroup, which means that bone mineral density is a protective factor to knee osteoarthritis.

关 键 词：组织构建 骨组织工程 骨关节炎 膝关节 骨质疏松症 指骨 骨密度 Kelgren-Lawrence分级 校正 亚组分析 

分 类 号：R318[医药卫生—生物医学工程]