趋化因子CXCL12/趋化因子受体CXCR7轴与心血管疾病的相关性  

Relevance of the chemokine CXCL12/CXCR7 axis in cardiovascular disease

作　　者：涂小丽[1] 吴延庆[1] 

机构地区：[1]南昌大学第二附属医院心血管内科,南昌330006

出　　处：《重庆医科大学学报》2015年第4期481-484,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:81260025;30800467)

摘　　要：趋化因子CXCL12(chemokine CXCL12,CXCL12)是一种能诱导细胞向高浓度方向定向运动的小分子多肽类物质,研究表明其能够通过调节造血干细胞、祖细胞的归巢、迁移及动员至外周环境,来保护组织在损伤刺激下的自我稳态。既往研究认为CXCL12的唯一受体是趋化因子受体4(C-X-C chemokine receptor 4,CXCR4),但研究表明其还存在另一个受体:趋化因子受体7(C-X-C chemokine receptor 7,CXCR7),它是一个非典型趋化因子受体家族,且不是通过激活G蛋白偶联受体而是通过与β抑制蛋白类相互作用,调节CXCL12的生物利用率以及上调或者下调CXCR4介导的活性及信号通路。本文主要讨论CXCR7在细胞增殖、血管生成、及细胞迁移方面的作用,以及其与心血管疾病之间的相关性。Chemokine receptor CXCL12 is a small protein that mediates cell chemotaxis. Previous studies confirmed that chemokine receptor CXCL12 was a principal regulator of homing,migration and mobilization of haematopoietic stem cells and endothelial progenitor cells（EPCs）during steady-state homeostasis and injury. Once previously thought to interact exclusively with CXCR4,CXCL12 also binds to CXCR7（recently renamed ACK3R）,which belongs to an atypical chemokine receptor family whose members fail to activate G proteins but interact with β-arrestins,control the CXCL12 bioavailability,enhance or dampen CXCR4- mediated signaling and activity.Here we discuss the role of CXCR7 in cell proliferation,angiogenesis,and metastasis,with a focus on cardiovascular disease.

关 键 词：趋化因子CXCL12 趋化因子受体7 心血管疾病 

分 类 号：R541.4[医药卫生—心血管疾病]