HLA-DQ遗传多态性与乙肝病毒感染结局相关  

Association of HLA-DQ gene polymorphisms with the outcomes of hepatitis B virus infection

作　　者：侯思慧 李青岭[2] 胡筠[1] 彭洪[1] 郭进军[1] 

机构地区：[1]重庆医科大学附属第二医院消化内科,重庆400010 [2]重庆医科大学生命科学研究院,重庆400016

出　　处：《基础医学与临床》2015年第7期873-878,共6页Basic and Clinical Medicine

基　　金：国家自然科学基金(30972583;81071338)

摘　　要：目的 探讨中国汉族人群人类白细胞抗原（HLA）-DQ基因单核苷酸多态性（rs9275572和rs9275319）与乙肝病毒感染结局的关系.方法 用TaqMan探针对纳入的921例样本进行HLA-DQrs9275572和rs9275319位点多态性的检测,921例血样本包括310例HBV相关慢性肝病者（CLD）、295例乙肝感染后自发清除者（SC）和316例健康对照者（HC）.结果 1）Rs9275572 AG基因型有利于乙肝感染后病毒自发清除（OR 1.82,95％ CI 1.26～2.62;显性基因模型：OR 1.84,95％ CI 1.30～2.61）.2）SNPrs9275319位点与乙肝易感性及感染后病毒的自发清除关系密切,携带rs9275319 C等位基因是一个保护因素（CLD vs HC：等位基因模型OR 0.49,95％ CI0.33 ～0.73,显性模型OR0.47,95％ CI0.31～0.72;CLD vs SC：等位基因模型OR 1.61,95％ CI 1.06～2.43,显性模型OR 1.57,95％口1.01 ～2.48）.3）单体型T-G/T-A与乙肝易感性及感染后病毒自发清除相关.结论 HLA-DQ基因多态性与乙肝易感性及感染后病毒的自发清除密切相关.Objective To assess the effect of two single nucleotide polymorphisms （rs9275572 and rs9275319）in human leukocyte antigen （HLA）-DQ gene on the outcomes of HBV infection in Chinese Han population.Methods HLA-DQ （rs9275572 and rs9275319） was genotyped in 921 subjects by TaqMan probe method,including 310 HBV-related chronic liver disease patients （CLD）,295 HBV spontaneous clearance subjects （SC） and 316 healthy control individuals （HC）.Results 1）rs9275572 AG genotype showed a significant protective effect on HBV clearance （OR 1.82,95％ CI 1.26 ～2.62;dominant genetic model：OR 1.84,95％ CI 1.30 ～2.61）.2） SNP rs9275319 showed a significant association with HBV susceptibility and HBV natural clearance.The rs9275319 C allele played a protective role （the allele model OR 0.49,95％ CI0.33 ～0.73;the dominant genetic model OR0.47,95％ CI 0.31 ～0.72 for CLD vs HC;the allele model,OR 1.61,95％ CI 1.06 ～2.43;the dominant genetic model OR 1.57;95％ CI 1.01 ～ 2.48 for CLD vs SC）.3） a conspicuous association was unveiled between haplotype T-G/T-A and HBV susceptibility or spontaneous clearance.Conclusions HLA-DQ gene polymorphisms are correlated with HBV susceptibility or nature clearance.

关 键 词：乙型肝炎 单核苷酸多态性(SNP) HLA-DQ基因 

分 类 号：R512.62[医药卫生—内科学]