姜黄素纳米粒的制备及药动学研究  

Preparation and Pharmacokinetic Evaluation of Curcumin-loaded Nanoparticles

作　　者：张文文[1] 张国喜[2] 孙考祥[1] 

机构地区：[1]烟台大学药学院,山东烟台264005 [2]南京绿叶思科药业有限公司,江苏南京210061

出　　处：《南京中医药大学学报》2015年第4期388-391,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金(81202861)

摘　　要：目的研究姜黄素纳米粒大鼠尾静脉注射后的药动学特性。方法采用乳化溶剂扩散法制备姜黄素纳米粒,大鼠尾静脉注射姜黄素纳米粒和游离姜黄素后,利用HPLC测定不同时间点血浆中药物浓度,DAS 3.0软件处理数据,求算药动学参数。结果姜黄素纳米粒给药后的药时曲线下面积AUC显著提高,分布容积和清除率显著降低。采用较大分子量聚合物制备的纳米粒具有更高的AUC、更低的分布容积和清除率,显示了更加优异的长循环特性,与体外释放的结果相吻合。结论姜黄素纳米粒在大鼠体内消除慢,能显著提高姜黄素的生物利用度。OBJECTIVE To study the intravenous pharmacokinetics of curcumin-loaded nanoparticles in SD rats. METH- ODS Curcumin-loaded nanoparticles were prepared with the method of emulsion solvent diffusion. Rats were administrated with curcumin-loaded nanoparticles and eurcumin solution （8.0 mg/kg） intravenously, eurcumin in plasma after administration was determined by HPLC and the results were analyzed using program DAS 3.0 to obtain the pharmacokinetie parameters. RESULTS After intravenous administration, the AUC_0-1 of curcumin-loaded nanoparticles increased obviously. The Volume of distribution （Vz） and Clearance （C1） of curcumin loaded nanoparticles decreased obviously compared with curcumin solubilized in PEG400 and ethanol, which demonstrated a prolonged circulation time as shown in release study in vitro. CONCLUSION The curcnmin-loaded nanoparticles were eliminated more slowly. The bioavailability of curcumin in rats increased remarkably compared with that of curcumin solution after intravenous administration.

关 键 词：姜黄素 纳米粒 体外释放 药代动力学 

分 类 号：R283.6[医药卫生—中药学]