小青龙汤对慢性阻塞性肺疾病寒痰蕴肺气道病理改变效果  

Efficacy of the Xiao Qinglong decoction on COPD airway pathology

作　　者：徐晓杰[1] 

机构地区：[1]南阳医学高等专科学校,河南南阳473003

出　　处：《中医临床研究》2015年第17期13-14,共2页Clinical Journal Of Chinese Medicine

摘　　要：目的:分析对慢性阻塞性肺疾病(寒痰蕴肺型)大鼠应用小青龙汤治疗前后气道的病理改变,探讨小青龙汤治疗此类疾病的可能机制。方法:选取健康的雄性SPF级Wistar大鼠30只,随机分为模型组及对照组,各15只。模型组大鼠采用改良烟熏加脂多糖加气管滴方法:复制慢性阻塞性肺疾病模型,然后将大鼠放入冰箱制作成寒痰温肺模型后,对其进行灌服小青龙汤治疗;对照组不做任何处理。光镜下观察两组大鼠的变化。结果:模型组气道及肺的形态及病理相对于对照组都发生了改变,应用小青龙汤治疗后好转。结论:小青龙汤治疗寒痰蕴肺型慢性阻塞性肺疾病效果良好。Objective: To analyze efficacy of the Xiao Qinglong decoction on COPD airway pathology. Methods: 30 healthy male wistar rats of SPF were randomly divided into the control group and the model group, 15 cases for each group. The model group modified smoking and intratracheal instillation of lipopolysaccharide, and then put them in the refrigerator to make retention of cold-phlegm in the lung model, and then took the Xiao Qinglong decoction; the control group did not do any processing. The transformation in two groups was observed. Results: Compared with the control group, the morphology and pathological of airway and lungs in model groups had changed. They were better after receiving the Xiao Qinglong decoction. Conclusion: The effect of the Xiao Qinglong decoction on COPD airway pathology is good.

关 键 词：小青龙汤 WISTAR大鼠 寒痰蕴肺 病理 

分 类 号：R322.35[医药卫生—人体解剖和组织胚胎学]