香术茯苓颗粒止泻、抗炎作用的实验研究  

Antidiarrheal and anti-inflammatory effects of Ageratum rhizoma Atractylodis Tuckahoe granules

作　　者：王宇翎[1] 张艳[1] 李前进[1] 舒宏敏 林杰[1] 杨梦媛[1] 朱韬[1] 罗欢[1] 

机构地区：[1]安徽医科大学基础医学院药理学教研室,合肥230032

出　　处：《安徽医科大学学报》2015年第7期988-990,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省高校省级自然科学研究项目(编号:KJ2013A146)

摘　　要：目的观察香术茯苓颗粒对动物模型的止泻、抗炎作用。方法通过蓖麻油和番泻叶建立两种小鼠腹泻模型,研究香术茯苓颗粒的止泻作用;采用二甲苯诱导小鼠耳肿胀模型,新鲜蛋清诱导大鼠足爪肿胀模型,观察香术茯苓颗粒的抗炎作用。结果香术茯苓颗粒9、18 g/kg 1次给药能减少蓖麻油引起的小鼠腹泻分值,香术茯苓颗粒18 g/kg 1次给药可减少番泻叶引起的小鼠腹泻分值;香术茯苓颗粒18 g/kg 1次给药对二甲苯诱导的小鼠耳肿胀有一定的抑制作用;香术茯苓颗粒16 g/kg 1次给药可抑制新鲜蛋清诱导大鼠足爪肿胀。结论香术茯苓颗粒对动物模型具有止泻作用和抗炎作用。Objective To study antidiarrheal and anti-inflammatory effects of Ageratum rhizoma Atractylodis Tucka-hoe granules （ ARTG） . Methods The diarrhea models of castor oil and senna leaf, dimethylbenzene-induced ear swelling and paw edema caused by egg white were used to study ARTG. Results ARTG（9,18 g/kg）single admin-istration could decrease the score of wet dung induced by castor oil, ARTG（18 g/kg） single administration could decrease the score of wet dung induced by senna leaf. ARTG （ 18 g/kg ） single administration could inhibit the swelling degree of ear in mice, ARTG（16 g/kg） single administration could reduce the paws swelling induced by egg white in rats. Conclusion ARTG has antidiarrheal and anti-inflammatory effects on animal models.

关 键 词：香术茯苓颗粒 止泻作用 抗炎作用 

分 类 号：R965.2[医药卫生—药理学]