抗骨结核缓释药物:载体材料的选择  

Sustained-released anti-tuberculosis drugs:a choice of carrier materials

作　　者：费正奇[1] 胡蕴玉[2] 

机构地区：[1]解放军第五医院骨科中心,宁夏回族自治区银川市750004 [2]解放军第四军医大学西京医院骨科研究所,陕西省西安市710032

出　　处：《中国组织工程研究》2015年第21期3387-3391,共5页Chinese Journal of Tissue Engineering Research

基　　金：2011宁夏自然科学基金资助项目(NZ11236)~~

摘　　要：背景:骨关节结核抗结核药物局部使用是目前常用的治疗方法,但由于结核药物吸收快,难以发挥持久抗结核作用,因而需要寻找一种能够使得抗菌药物缓慢释放达到持久治疗效果的理想药物载体。目的:总结分析目前抗结核缓释药物的研究进展。方法:由第一作者应用计算机检索1990年1月至2014年12月PubM ed数据库、维普中文期刊网有关抗骨结核缓释药物文章,检索英文关键词为"osteoarticular tuberculosis;anti-tuberculosis;sustained-released drugs",中文关键词为"骨关节结核;抗结核;缓释药物"。结果与结论:目前抗结核药物研究常用的缓释载体有无机材料、高分子材料和生物材料3大类。无机材料包括有磷酸钙、硫酸钙及碳酸钙等,高分子材料主要包有聚乳酸、聚乙醇酸、聚乳酸-乙醇酸共聚物,生物类材料包括蛋白、明胶、藻酸盐、甲壳素、脱矿骨基质等。每种材料有着其固有的优势和弊端,还不能充分具备作为理想载体材料的所有条件。不同材料的复合可相互取长补短,为今后载体材料改进的研究方向。BACKGROUND：Local administration of anti-tuberculosis drugs is a commonly used therapy. Due to the rapid absorption, the drugs cannot have the durable therapy effect; therefore, it is necessary to seek an optimal carrier material for the agents. OBJECTIVE：To review the new development for the carrier materials of anti-tuberculosis drugs. METHODS：A computer-based search of PubMed and VIP databases was performed by the first author to search articles related to sustained-released anti-tuberculosis drugs published from January 1990 to December 2014. The key words were ＂osteoarticular tuberculosis; anti-tuberculosis; sustained-released drugs＂ in English and Chinese, respectively. RESULTS AND CONCLUSION：Inorganic materials （calcium phosphate, calcium sulfate）, polymer materials （polylactic acid, polyglycolic acid, polylactic-co-glycolic acid） and biomaterials （protein, glutin, alginates, chitin, demineralized bone matrix） are the main three kinds of carrier materials for anti-tuberculosis drugs. These carrier materials have their own advantages and disadvantages, which cannot be the optimal carrier materials. However, the complex of these materials is a promising technology for the optimal carrier materials in the future.

关 键 词：生物材料 缓释材料 抗结核 缓释药物 骨关节结核 宁夏自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]