透明质酸复合材料研究现状  

Research status of hyaluronan composite materials

作　　者：丁金聚 孙伟庆 

机构地区：[1]杭州协合医疗用品有限公司,浙江省杭州市310018

出　　处：《中国组织工程研究》2015年第21期3403-3408,共6页Chinese Journal of Tissue Engineering Research

基　　金：科技部国际合作项目(2015DFA51010)~~

摘　　要：背景:透明质酸具有独特的线性大分子结构和流变性性能,具有良好的生物相容性且为细胞表面信号识别物质,在组织工程领域具有较好的应用潜力。目的:综述透明质酸复合物在医用材料方面的研究进展。方法:查阅国内外有关透明质酸复合物在制备、安全性评价和临床试验方面的相关文献,归纳总结透明质酸复合物在软骨支架、角膜支架和黏膜填充剂3个方面的研究进展。结果与结论:透明质酸复合物具有适当的空隙、仿生的三维微观结构、良好的理化性能和生物学性能等优势,使其在软骨支架和角膜支架应用方面展现应用潜能。透明质酸复合物作为黏膜填充剂已实现临床应用,报道的治疗有效率低和部分并发症需进一步研究,由于黏膜组织质地疏松,要求复合物在设计上要具有更为长期的稳定性。BACKGROUND：Hyaluronan with special linear macromolecular structure and rheologic property has good biocompatibility and becomes a signal matter of the cel surface, which possesses a promising application potential in tissue-engineering field. OBJECTIVE：To review the research progress in medical hyaluronan composites. METHODS：Related literatures concerning preparation, safety evaluation and clinical trials of hyaluronan composites were extensively reviewed and comprehensively analyzed in the three folowing aspects： cartilage scaffold, cornea scaffold and submucous bulking agent. RESULTS AND CONCLUSION：The hyaluronan composite has a potential use in cartilage scaffold and cornea scaffold as its suitable porosity and pore size, biomimetic three-dimensional microstructure, excelent physical and chemical property and biological property. The hyaluronan composite as a bulking agent has been applied clinicaly, and results from some clinical trials have shown that the composite used as bulking agent has the problems about low efficacy and complications, which need to do further improvement. More researches are needed in product design, evaluation of performance and safety for expending and optimizing the clinical applications of the hyaluronan composite.

关 键 词：生物材料 材料相容性 透明质酸 复合材料 支架 填充材料 角膜支架 软骨支架 

分 类 号：R318[医药卫生—生物医学工程]