联合填充生物材料矫正单侧唇裂术后畸形  

Comprehensive procedures with biomaterial filling for secondary unilateral cleft lip nasal deformity

作　　者：万程[1] 王喜梅[1] 郭丽丽[1] 董海江[1] 李想[1] 

机构地区：[1]郑州大学第一附属医院整形外科,河南省郑州市450052

出　　处：《中国组织工程研究》2015年第21期3434-3439,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:目前用于矫正单侧唇裂后畸形的常用填充植入材料有耳甲腔软骨、肋软骨、Medpor种植体、膨体聚四氟乙烯假体及脱细胞异体真皮等。目的:分析辅助应用脱细胞异体真皮与膨体聚四氟乙烯假体矫正单侧唇裂继发唇鼻畸形的疗效。方法:纳入单侧唇裂术后唇鼻畸形患者36例,其中男19例,女17例,年龄15-32岁,在唇鼻畸形综合修复中辅助应用脱细胞异体真皮(n=22)或膨体聚四氟乙烯假体(n=14)矫正鼻基底塌陷畸形。采用人体测量学方法制定测量指标,定点测量患者矫正前后的随访照片,对两种填充材料的远期效果进行客观定量分析与评价。结果与结论:随访6个月,患者对鼻部外形满意,均无感染及外露,未发生与填充材料相关的不良反应。脱细胞异体真皮组疗效中优16例,良6例;膨体聚四氟乙烯假体组疗效中优10例,良4例。两组随访6个月的客观指标检测结果均明显优于矫正前(P<0.05),并且两组间各客观指标检测结果比较差异无显著性意义(P>0.05)。表明脱细胞异体真皮与膨体聚四氟乙烯假体在单侧唇裂继发唇鼻畸形的矫治中可较好恢复鼻部外形,远期外观保持良好。BACKGROUND：At present, the common filing materials used to correct secondary unilateral cleft lip nasal deformity include conchae cartilage, costal cartilage, Medpor implants, expanded polytetrafluoroethylene （ePTFE）, alogenic acelular dermal matrix. OBJECTIVE：To analyze the therapeutic effects of comprehensive procedures with alogenic acelular dermal matrix or ePTFE for secondary unilateral cleft lip nasal deformity. METHODS： Thirty-six patients with secondary unilateral cleft lip nasal deformity were enroled, including 19 males and 17 females, aged 15-32 years. Alogenic acelular dermal matrix （n=22） or ePTFE （n=14） was used to correct nasal base colapse deformities. Anthropometry method was employed to make measurements. Fixed-point measurement was performed based on patient＇s pictures before and after correction. Long-term effects of these two kinds of filing materials were analyzed and assessed objectively and quantitatively. RESULTS AND CONCLUSION： After the folow-up of 6 months, al the patients were satisfied with their results, and no infection and no exposure occurred. The treatment effect of the alogenic acelular dermal matrix group was excelent in 16 cases and good in 6 cases; there were 10 cases of excelent and 4 cases of good in the ePTFE group. The objective indicators in the two groups were al improved at 6 months after correction （P 0.05）. These findings indicate that alogenic acelular dermal matrix or ePTFE is useful to correct secondary unilateral cleft lip nasal deformity.

关 键 词：生物材料 材料相容性 单侧唇裂继发唇鼻畸形 脱细胞异体真皮 膨体聚四氟乙烯 客观定量分析 

分 类 号：R318[医药卫生—生物医学工程]