红细胞分布宽度与甲状腺相关性眼病相关  

Red blood cell distribution width is elevated in patients with Graves' ophthalmopathy

作　　者：曾程程 魏锐利[1] 牟旆 王秋红[1] 

机构地区：[1]第二军医大学长征医院眼科,上海200003

出　　处：《第二军医大学学报》2015年第6期680-684,共5页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81371056)~~

摘　　要：目的探讨红细胞分布宽度(red cell distribution width,RDW)与甲状腺相关性眼病(thyroid-associated ophthalmopathy,TAO)的关系。方法收集52例格雷夫斯病(Graves’disease,GD)患者[男18例、女34例,39例有格雷夫斯眼病(Graves’ophthalmopathy,GO)表现]和22例健康对照者(男8例、女14例)资料。所有患者均检测RDW和甲状腺功能,GD组患者检查眼球突出度和临床活动性评分(CAS),比较组间差异。结果 GD患者的甲状腺功能各项指标与健康对照者相比差异有统计学意义(P<0.05);在GD患者中,有GO表现者和无GO表现者之间甲状腺功能相关指标差异无统计学意义,但有GO表现者的眼球突出度值高于无GO表现者(P<0.05)。GD患者的RDW高于健康对照者(P<0.05);在GD患者中,RDW与CAS评分呈现平行增加,且有GO表现者的RDW高于无GO表现者(P<0.05)。结论 RDW与GD患者和GO患者的病情相关,提示RDW可间接为评估病情的轻重提供依据。Objective To study the relationship between red blood cell distribution width（RDW）and thyroid associated ophthalmopathy（TAO）.Methods Fifty-two patients with Graves’ disease（GD,18 males and 34 females,39cases of GD patients with Graves’ ophthalmopathy[GO]）and 22 healthy controls（8 males and 14females）were recruited in the present study.The RDW and thyroid functions were measured in all participants.Ophthalmological examinations including Hertel’s exophthalmometer readings（HER）and clinical activity score（CAS）evaluation were obtained in GD patients,and the results were compared between different groups.Results Thyroid functions were significantly different between GD patients and healthy controls（P〈0.05）,while they were not between GD patients with or without GO;the HER level was significantly higher in those with GO compared with those without GO（P〈0.05）.The RDW value in patients with GD was significantly higher than that in the healthy controls（P〈0.05）.For GD patients,RDW increased with the increase of CAS,and those with GO had significantly higher RDW than those without GO（P〈0.05）.Conclusion RDW is associated with the state of the GD patients,indicating that RDW may provide evidence for assessing the severity of GO.

关 键 词：甲状腺相关性眼病 格雷夫斯病 自身免疫性疾病 红细胞分布宽度 

分 类 号：R581.11[医药卫生—内分泌]