干细胞与再生医学研究进展  

Progress in stem cells and regenerative medicine

作　　者：王立宾[1] 祝贺[1] 郝捷[1] 周琪[1] 

机构地区：[1]中国科学院动物研究所计划生育生殖生物学国家重点实验室,北京100101

出　　处：《生物工程学报》2015年第6期871-879,共9页Chinese Journal of Biotechnology

基　　金：国家国际科技合作专项(No.2013DFG30680)资助~~

摘　　要：干细胞具有分化成为体内所有类型细胞的能力,因此,其在再生医学治疗、体外疾病模拟、药物筛选等方面具有广阔的应用前景。干细胞技术在近些年取得了突飞猛进的发展,特别是诱导多能性干细胞的出现使干细胞领域经历了一场巨大的变革。我国干细胞研究在这场干细胞技术变革中取得了多项重大成果,逐渐成为了世界干细胞研究领域中的重要力量。本综述着重介绍近几年来,主要是诱导多能性干细胞技术出现之后,我国在干细胞和再生医学领域取得的重要进展,主要涵盖诱导多能性干细胞、转分化、单倍体干细胞以及基因修饰动物模型和基因治疗等方面。Stem cells have the ability to differentiate into all types of cells in the body and therefore have great application potential in regenerative medicine, in vitro disease modelling and drug screening. In recent years, stem cell technology has made great progress, and induced pluripotent stem cell technology revolutionizes the whole stem cell field. At the same time, stem cell research in our country has also achieved great progress and becomes an indispensable power in the worldwide stem cell research field. This review mainly focuses on the research progress in stem cells and regenerative medicine in our country since the advent of induced pluripotent stem cell technology, including induced pluripotent stem cells, transdifferentiation, haploid stem cells, and new gene editing tools.

关 键 词：干细胞 诱导多能性干细胞 转分化 单倍体干细胞 CRISPR/Cas9 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]