山东某高校青年人群尿液中吡咯加合物医学参考值范围测定  

Determination of normal reference value of pyrrole adducts in urine in young people in a university in Shandong, China

作　　者：王辉[1] 王译苹 周振伟[1] 王硕[1] 尹洪银[1] 谢克勤[1] 

机构地区：[1]山东大学公共卫生学院毒理学研究所,济南250012

出　　处：《中华劳动卫生职业病杂志》2015年第6期435-437,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金（81373044）;教育部博士点基金（20120131110058）

摘　　要：目的 测定山东某高校正常青年人群尿液中吡咯加合物的医学参考值范围,为正己烷中毒的临床诊断提供依据.方法 随机选择山东某大学学生240人,去除不合格者32人,共208例为研究对象.其中男女各104人,年龄（18～24）岁,平均（21±3）岁.尿样为晨尿.采用比色法测定尿液中吡咯加合物的含量.结果 测定的正常青年人群男女尿液中吡咯加合物含量均为正偏态分布;男性尿液中吡咯加合物含量的中位数是0.88 nmol/ml,参考值范围为（0.14～3.92） nmol/ml;女性尿液中吡咯加合物含量的中位数为0.93 nmol/ml,参考值范围为（0.09～3.27） nmol/ml.男性与女性尿液中吡咯加合物浓度差异无统计学意义（t=0.15,P＞0.05）.结论 该研究测定的正常青年人群尿液中吡咯加合物含量中位数为0.91 nmo1/ml,参考值范围为（0.11～3.95） nmol/ml.Objective To determine the normal reference value of pyrrole adducts in urine in young people in a university in Shandong,China,and to provide a reliable basis for the clinical diagnosis of n-hexane poisoning.Methods A total of 240 college students were randomly selected.After excluding 32 ineligible students,208 subjects were included in this study,consisting of 104 males and 104 females,with a mean age of 21±3 years （range：18 to 24 years）.Morning urine was collected from each subject.The content of pyrrole adducts was determined by chromatometry.Results The content of pyrrole adducts in both male and female obeyed a positively skewed distribution.The median level of pyrrole adducts in male subjects was 0.88 nmol/ml,and the reference value was 0.14～3.92 nmol/ml.The median level of pyrrole adducts in female subjects was 0.93 nmol/ml,and the reference value was 0.09～3.27 nmol/ml.Student＆#39; s t test identified no statistical difference in pyrrole adduct level between male and female subjects （t=0.15,P〉0.05）.Conclusion The median level of pyrrole adducts in normal young people is 0.91 nmol/ml,and the reference value is 0.11～3.95 nmol/ml.

关 键 词：吡咯加合物 医学参考值 尿 

分 类 号：R446.12[医药卫生—诊断学]