蝎毒素与小电导钙激活钾通道独特的相互作用(英文)  

Unique interactions between scorpion toxins and small conductance Ca^(2+)-activated potassium channels

作　　者：杨帆[1] 陈宗运[2] 吴英亮[1] 

机构地区：[1]武汉大学生命科学学院,病毒学国家重点实验室,武汉430072 [2]湖北医药学院基础医学院生物化学和分子生物学系,医药大分子实验室,十堰442000

出　　处：《生理学报》2015年第3期255-260,共6页Acta Physiologica Sinica

基　　金：supported by grants from the National Basic Research Development Program of China(No.2010CB529800);the National Natural Sciences Foundation of China(No.31170789,31200557);the New Century Excellent Talents in Wuhan University by the Ministry of Education of China(No.NCET-10-0651)

摘　　要：分布在神经系统中的小电导Ca2+激活钾通道(small conductance Ca2+-activated potassium channels,SK通道)在学习、记忆及突触的可塑性过程中发挥了重要的作用。利用短链蝎毒素揭示了SK通道大部分药理学性质。不同于大部分电压门控钾通道和大电导Ca2+激活钾通道,SK通道电流仅能被少量蝎毒素抑制。近来,研究揭示了SK通道选择性识别毒素的结构基础是SK通道细胞外孔区部位存在一种新颖的多肽筛选器。本综述总结了蝎毒素与SK通道独特的相互作用,这不仅对深入研究SK通道生理功能具有重要的作用,而且有助于促进SK通道相关疾病的药物开发。Small conductance Ca^2＋-activated potassium channels（SK channels） distributing in the nervous system play an important role in learning, memory and synaptic plasticity. Most pharmacological properties of them are determined by short-chain scorpion toxins. Different from most voltage-gated potassium channels and large-conductance Ca^2＋-activated potassium channels, SK channels are only inhibited by a small quantity of scorpion toxins. Recently, a novel peptide screener in the extracellular pore entryway of SK channels was considered as the structural basis of toxin selective recognition. In this review, we summarized the unique interactions between scorpion toxins and SK channels, which is crucial not only in deep-researching for physiological function of SK channels, but also in developing drugs for SK channel-related diseases.

关 键 词：蛋白-蛋白相互作用 多肽筛选器 钾通道 α-KTx 

分 类 号：Q51[生物学—生物化学]