N-端脑钠肽和左心房容积指数评价心房颤动患者左心室舒张功能价值  被引量:3

Value of N-terminal B-type natriuretic peptide and left atrial volume index to the evaluation of left ventricular diastolic function in atrial fibrillation patients

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作  者:刘彤[1] 刘心遥[2] 张建强[3] 董建增[1] 马长生[1] 

机构地区:[1]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所心内科,北京100029 [2]北京同仁医院心血管中心,北京100041 [3]北京航天中心医院心脏疾病诊疗中心,北京100049

出  处:《中华实用诊断与治疗杂志》2015年第7期640-642,共3页Journal of Chinese Practical Diagnosis and Therapy

基  金:首都临床特色应用研究基金(Z121107001012068)

摘  要:目的 探讨N-端脑钠肽和左心房容积指数评价心房颤动(房颤)患者左心室舒张功能的价值。方法 行首次射频消融治疗的孤立性房颤患者47例,根据左心室舒张功能情况分为左心室功能正常组37例(E/e〈10)和左心室功能不全组10例(E/e〉10),比较2组血清N-端脑钠肽(N-terminal B-type natriuretic peptide,NT-pro BNP)水平和心脏超声指标。结果 左心室舒张功能不全组血浆BNP水平[94(78.7,223.71)ng/L]、左心房容积指数[(39.9±11.6)mL/m2]明显高于左心室舒张功能正常组[54.8(39.7,89.9)ng/L、(32.1±7.4)mL/m2](P〈0.05);BNP对数、左心房容积指数及2个指标联合判断房颤患者左心室舒张功能不全的AUC分别为0.801(95%CI:0.653~0.949,P=0.009)、0.741(95%CI:0.535~0.947,P=0.036)、0.810(95%CI:0.658~0.963,P=0.007)。结论 BNP和左心房容积指数联合检测可作为早期房颤患者左心室舒张功能不全的诊断指标之一。Objective To evaluate the value of N-terminal B-type natriuretic peptide (BNP) and left atrial volume index (LAVI) to the evaluation of left ventricular diastolic function (LVDF) in atrial fibrillation patients. Methods Forty seven patients receiving initial catheter radiofrequency ablation for lone arterial fibrillation were divided into normal LVDF group (n=37) (E/e'〈10) and abnormal LVDF group (n:10) (E/e'〉10). BNP levels and cardiac ultrasound indexes were compared between two groups. Results BNP level and LAVI were significantly higher in abnormal LVDF group (94(78.7, 223.7) ng/L, (39.9±11.6) mL/m2) than those in normal LVDFgroup (54.8(39.7, 89.9) ng/L, (32. 1± 7.4) mL/m2) (P〈0.05). AUC values of BNP, LAVI and BNP plus LAVI for left ventricular diastolic dysfunction were 0.801 (95% CI: 0.653 to0.949, P=0.009), 0.741 (95MCI: 0.535 to 0.947, P=0.036) and 0.810 (95% CI: 0.658 to 0. 963, P=0. 007). Conclusion The combination detection of BNP and LAVI may be used as one of the diagnosis indexes of left ventricular diastolic dysfunction in patients with atrial fibrillation.

关 键 词:心房颤动 左心室舒张功能 N-端脑钠肽 左心房容积指数 

分 类 号:R541.75[医药卫生—心血管疾病]

 

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