肾囊阻滞对大鼠胃肌电活动与胃动力的影响  

Influence of renal capsule block on gastric myoelectrical activity and motility in rats

作　　者：唐永忠[1] 廖琴[1] 陆希[1] 

机构地区：[1]中南大学湘雅三医院麻醉科,湖南长沙410013

出　　处：《中国普通外科杂志》2015年第6期834-837,共4页China Journal of General Surgery

摘　　要：目的:探讨肾囊阻滞对胃肌电活动与胃动力的影响,为用该法治疗胃肠动力紊乱性疾病提供理论依据。方法:将36只雄性SD大鼠随机均分为3组,分别腹腔注射阿托品、新斯的明、生理盐水制作胃肠运动抑制模型(抑制组)、胃肠运动亢进模型(亢进组)、正常对照模型(对照组),各组大鼠造模后均以肾囊注射利多卡因行肾囊阻滞处理。检测各组大鼠胃电信号与胃残留率并比较。结果:造模后,与对照组比较,抑制组胃电平均峰峰值与平均周期均明显降低,胃残留率明显增加,而亢进组各项指标变化正好相反(均P<0.05)。肾囊阻滞前比较,肾囊阻滞后,对照组各项指标无明显改变(均P>0.05);抑制组胃电平均峰峰值与平均周期均较肾囊阻滞前明显升高,而胃残留率明显减少(均P<0.05);亢进组胃电平均峰峰值与平均周期均较肾囊阻滞前明显降低,而胃残留率明显增加(均P<0.05)。结论:肾囊阻滞对正常胃电活动与运动功能无明显影响,但对异常胃电活动与运动功能则有双向调整作用。Objective： To investigate the influence of renal capsule block on gastric myoelectrical activity and motility in rats, and provide a theoretical basis for using this method in treatment of gastrointestinal motor disorders.Methods： Thirty-six SD rats were equally randomized into 3 groups, and then underwent intraperitoneal injection of atropine, neostigmine or normal saline to create the models of gastrointestinal motor suppression（suppression group）, gastrointestinal hyperactivity（hyperactivity group）, or normal control（control group）, respectively. Rats in each group underwent renal capsule block procedure by renal capsule injection of lidocaine. The gastric electrical activity and gastric residual rate in rats of each group were detected and compared.Results： Compared with control group after model creation, the average peak amplitude and cycle length of the electrogastrography were reduced, and gastric residual rate was increased significantly in suppression group, while the changes in these parameters in hyperactivity group were opposite to those in hyperactivity group（all P0.05）. After renal capsule block, all the parameters in control group showed no significant change compared with those before renal capsule block（all P0.05）, while the average peak amplitude and cycle length of the electrogastrography in suppression group were elevated and gastric residual rate was decreased significantly compared with the values before renal capsule block, and the average peak amplitude and cycle length of the electrogastrography in hyperactivity group were decreased and gastric residual rate was increased significantly compared with those before renal capsule block（all P0.05）.Conclusion： Renal capsule block exerts no obvious impact on normal gastric myoelectrical activity and motility, but has a bidirectional correction ef ect on abnormal gastric myoelectrical activity and motility.

关 键 词：神经传导阻滞 胃电描记术 胃肠活动 

分 类 号：R614.4[医药卫生—麻醉学]