Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen  

作　　者：Ziqiang Zhou Dongping Ye Weiguo Liang Bin Wang Zhenzhong Zhu 

机构地区：[1]Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University, Guangzhou 510220, China

出　　处：《Chinese Journal of Traumatology》2015年第1期33-38,共6页中华创伤杂志（英文版）

摘　　要：Purpose： To develop a novel injectable strontium-containing calcium phosphate cement with collagen. Methods： A novel calcium phosphate bone cement （CPC） was prepared with the addition of strontium element, collagenl, and modified starch; the injectability, solidification time, microstructure, phase composition, compressive strength, anti-collapsibility and histological properties of material were evaluated. Results： The results showed that the material could be injected with an excellent performance; the modified starch significantly improved the anti-washout property of cement; with the liquid to solid ratio of 0.3, the largest compressive strength of cement was obtained （48.0 MPa _＋ 2.3 MPa）; histological examination of repair tissue showed that the bone was repaired after 16 weeks; the degradation of cement was consistent with the new bone growth. Conclusion： A novel injectable collagen-strontium-containing CPC with excellent compressive strength and suitable setting time was prepared, with addition of modified starch. The CPC showed a good anti-washout property and the degradation time of the cement met with the new bone growing. This material is supposed to be used in orthopedic and maxillofacial surgery for bone defects.

关 键 词：Calcium phosphate cement INJECTABILITY Compressive strength 

分 类 号：TQ172.7[化学工程—水泥工业] Q253[化学工程—硅酸盐工业]