前颅窝开放粉碎性骨折膜性颅底重建  

作　　者：林其昌[1] 林少华[1] 黄汉添[1] 廖巍[1] 

机构地区：[1]中山大学附属中山医院神经外科,广东中山528400

出　　处：《中华神经外科疾病研究杂志》2015年第3期264-265,共2页Chinese Journal of Neurosurgical Disease Research

基　　金：中山市科技局第二批科技计划基金资助项目(20132A125)

摘　　要：创伤性前颅窝粉碎性骨折是颅脑损伤的一种特殊类型，手术处理难度较大［1］。本研究选取2008年1月至2013年12月我院收治的前颅窝开放性粉碎性骨折48例，均予急诊手术行颅内血肿清除、骨折清创、颅底膜性重建，治疗效果理想，现报告如下。Background Clinical outcome in patients with severe traumatic brain injury ( TBI) depends on both primary and seconda-ry brain injuries.Neuroinflammation is an important secondary mechanism, which occurs by releasing interleukins ( ILs ) .Increased levels of ILs may affect clinical outcome following TBI.OBJECTIVE This study aimed to determine the relationship between the serum levels of interleukins 6, 8 and 10 and clinical outcome in patients with severe TBI 6 months after injury.PATIENTS And METHODS In a descriptive-analytical study, 44 patients with GCS≤8 ( Glasgow coma scale) and age≥14 years were included.Their blood samples were collected at first 6 hours after injury.Clinical outcome was determined based on GOS ( Glasgow Outcome Scale) at 6 months after head injury.Serum levels of interleukins 6, 8 and 10 were measured using the ELISA method.Spearmanˊs rho, independent T-Test, and Mann-Whitney Test were used for data analysis.RESULTS Comparing the serum levels of interleukins in two groups with favorable and unfavorable clinical outcomes showed that the mean serum levels of interleukins 6 and 8 in group with favorable outcome was 85.2 ±51.6 and 52.2 ±31.9, respectively lower than those of group with unfavorable outcome with 162.3 ±141.1 and 173.6 ±257.3 (P<0.03) and (P<0.01).CONCLUSIONS Increased serum levels of interleukins 6 and 8 as a predictive marker might be associated with unfa-vorable clinical outcome in patients with severe TBI.

关 键 词：颅前窝 膜性颅底重建 脑脊液漏 

分 类 号：R683.420.5[医药卫生—骨科学]