N-甲基-D-天冬氨酸受体拮抗剂美金刚抑制小鼠条件性恐惧记忆  

Effect of NMDA Receptor Antagonist Memantine on the Conditioned Fear Memory in Mice

作　　者：徐春华[1] 黄思琪[1] 杨华佳[1] 黄璐璐[1] 吕秀依[1] 周文华[1] 

机构地区：[1]宁波大学医学院

出　　处：《神经药理学报》2014年第2期22-26,共5页Acta Neuropharmacologica

基　　金：国家自然科学基金项目(No.U1132602;No.81071077)

摘　　要：观察N-甲基-D天冬氨酸(N-methyl-D-aspartic acid receptor,NMDA)受体拮抗剂美金刚对小鼠条件性恐惧记忆的影响。将小鼠随机分成生理盐水组、美金刚低剂量组、美金刚高剂量组。通过三种不同的给药时间和测试方法来检测不同情况下小鼠的僵直度。结果表明,急性药物预处理过程中,不同剂量的美金刚对小鼠的短期和长期记忆有不同的影响,而药物对小鼠恐惧记忆的消退没有显著作用。由此可见,美金刚对小鼠的条件恐惧记忆能够产生一定的作用,此作用随药物浓度和药物处理方式的不同而改变。NMDA receptor antagonist memantine is selected to examine the effects for the conditioned fear memory on mice. The mice were randomized into normal saline group, low dose group and high dose group. The percentage of mice freezing in different drug interventions was tested. The result showed that memantine dose-dependently affected the long-term and short-term memory of mice differently. However, memantine did not affect the extinction of fear memory. Consequently, memantine could affect the conditioned fear memory of mice and the effect varied according to the drug doses and interventions.

关 键 词：美金刚 条件性恐惧记忆 僵直度 

分 类 号：R964[医药卫生—药理学]