坤泰胶囊对排卵障碍性不孕症患者卵泡发育、子宫内膜及排卵的影响  

Influence by Kuntai capsule on follicular development, endometrium and ovulation in ovulation failure infertility patients

作　　者：吴翠杰[1] 

机构地区：[1]安阳市中医院妇产科,455000

出　　处：《中国实用医药》2015年第18期10-12,共3页China Practical Medicine

摘　　要：目的探讨中成药坤泰胶囊对排卵障碍性不孕症患者卵泡发育、子宫内膜及排卵的影响。方法选取排卵障碍性不孕症患者210例,随机分成A、B、C三组,各70例。A组口服坤泰胶囊,B组口服克罗米芬,C组口服坤泰胶囊+克罗米芬,观察三组患者的卵泡大小、数目、子宫内膜厚度及类型。出现成熟卵泡再重新分组,Ⅰ组口服坤泰胶囊,直至排卵,Ⅱ组肌内注射人绒毛膜促性腺激素(HCG),观察两组患者排卵及卵泡黄素化情况。结果 B、C两组成熟卵泡数、排卵率均高于A组,差异具有统计学意义(P<0.01),但B、C组间比较,差异无统计学意义(P>0.05)。A、C两组子宫内膜厚度及类型优于B组,差异有统计学意义(P<0.01),但A、C组间差异无统计学意义(P>0.05)。Ⅰ、Ⅱ两组血清雌二醇(E2)≥3000 pg/ml的例数和排卵率,差异无统计学意义(P>0.05),Ⅰ组卵泡黄素化率明显小于Ⅱ组,差异有统计学意义(P<0.05)。结论坤泰胶囊对卵子发育成熟、改善子宫内膜容受性、卵子排出具有明显效果。Objective To investigate the influence of Chinese patent medicine Kuntai capsule on follicular development, endometrium and ovulation in ovulation failure infertility patients. Methods A total of 210 ovulation failure infertility patients were randomly divided into groups A, B and C, with 70 cases in each group. Group A received Kuntai capsule through oral administration, group B received clomiphene through oral administration, and group C received Kuntai capsule＋clomiphene through oral administration. Size, number of follicular, thickness and type of endometrium were observed in the three groups. Patients with mature follicle were divided into new groups. Group Ⅰ received Kuntai capsule through oral administration till ovulation, and group Ⅱ received human chorionic gonadotropin（HCG） through intramuscular injection. Ovulation and follicle luteinization were observed in the two groups. Results Groups B and C had higher mature follicle number and ovulation rate group A, and their difference had statistical significance（P〈0.01）, while the difference between group B and group C had no statistical significance（P〈0.05）. Groups A and C had better thickness and type of endometrium, and the difference had statistical significance（P〈0.01）, while the difference between group A and group C had no statistical significance（P〈0.05）. The difference of cases with serum estradiol（E2） ≥ 3000 pg/ml and ovulation rate between group Ⅰ and group Ⅱ had no statistical significance（P〈0.05）. Group Ⅰ had much lower follicle luteinization rate than group Ⅱ, and their difference had statistical significance（P〈0.05）. Conclusion Kuntai capsule provides obvious effects for ovum development, improving receptivity of endometrium and ovulation.

关 键 词：不孕症 排卵障碍 坤泰胶囊 克罗米芬 人绒毛膜促性腺激素 疗效 

分 类 号：R711.6[医药卫生—妇产科学]