术后谵妄与脑损伤相关生物学标记物关系分析  

Analysis of relationship between postoperative delirium and related biological markers of cerebral injury

作　　者：刘卫华[1] 杜良琴[1] 莫娴婷 李恒[1] 

机构地区：[1]广东省清远市人民医院,511500

出　　处：《中国实用医药》2015年第18期30-31,共2页China Practical Medicine

摘　　要：目的分析全身麻醉患者术后谵妄(PD)与脑损伤相关生物学标记物的关系。方法 90例择期全身麻醉患者,于术前1 d和术后苏醒期采用意识错乱评估法(CAM)量表进行谵妄状态评定,术后发生谵妄的患者为谵妄组(45例),未发生谵妄的患者为非谵妄组(45例)。并分别于术前、苏醒期,抽取血清用酶联免疫吸附法(ELASA)测定S100β、神经无特异性烯醇化酶(NSE)值。结果血清S100β蛋白、NSE值在术后谵妄患者和非谵妄患者间,差异无统计学意义(P>0.05)。结论血清S100β蛋白、NSE与术后谵妄发生无明显相关性。Objective To analyze the relationship between postoperative delirium（PD） and related biological markers of cerebral injury. Methods There were 90 patients receiving general anesthesia, and they received confusion assessment method（CAM） scale for delirium assessment in 1 d before operation and in postoperative revival period. Patients with postoperative delirium were in delirium group（45 cases）, and those without delirium were in non-delirium group（45 cases）. Enzyme-linked immuno sorbent assay（ELISA） was applied for S100β protein and neuron specific enolase（NSE） value in serum before operation and in revival period. Results There was no statistically significant difference of serum S100β protein and NSE value between postoperative delirium patients and non-delirium patients（P〈0.05）. Conclusion Serum S100β protein and NSE have no obvious relationship with postoperative delirium.

关 键 词：术后谵妄 生物学标记物 S100Β蛋白 神经元特异性烯醇化酶 

分 类 号：R651.15[医药卫生—外科学]