4种复方丹参中药的精确分类及药效的理论评价  

The Accurate Classification of Four Kinds of Compound Danshen Medicines and Theoretical Evaluation of Their Medical Efficiency

作　　者：邹华彬[1] 王玲玲 杜爱琴[1] 史培猛 

机构地区：[1]山东大学化学与化工学院,济南250100 [2]山东省中药研究院,济南250014

出　　处：《世界中医药》2015年第6期904-909,共6页World Chinese Medicine

基　　金：山东省中医药科技发展计划项目(编号:2013-157)

摘　　要：目的:对4种复方丹参类中药进行精确分类并提出了相似配伍复方的药效理论评价方法。方法:基于双指标等级序列个性化模式识别法确定每个复方的特征序列并对相似配伍复方进行精确分类,根据分类结果进一步确定每个样品的核心特征序列及关联序列。每个样品特征序列中关联序列的样品数与该类样品的总数的比值定义为药效关联度。该参数可以很好地衡量关联序列代表的中药复方与核心特征序列代表的复方的药效相近程度。结果:测试并分析了4种23个中成药样品的氯仿提取物的红外指纹图谱。双指标等级序列个性化模式识别理论方法可以对这些样品进行品种的精确鉴别,样品正确判别率为96%。分析了4种复方之间的关联度,并初步发现两种复方药效的相似程度与其关联度近成正比关系。结论:该研究建立的中药药效理论评价方法,为探索中药药效研究提供了新思路。Objective： To carry out accurate classification of four kinds of compound Danshen medicines and to propose the concept of accurate theoretical estimation of Chinese medicines efficiency. Methods： Characteristic sequence of each sample was determined relying on the dual index grade sequence individualized pattern recognition method,and the accurate identification of samples with similar composition of medicines was performed. Then the ratio of samples in correlation sequence of one samples characteristic sequence to the total samples,which belonged to the same class of the samples in the correlation sequence,was defined as the correlation degree parameter,in order to investigate theoretical approach for estimating efficiency of Chinese medicines with close composition. Results： The IR fingerprint spectra of 23 samples components,belonging to four kinds of similar compound formulae containing Salvia miltiorrhiza,extracted with chloroform were measured,and were analyzed relying on dual index grade sequence individualized pattern recognition method,and then their correlation degree analysis were carried out. As a result,these samples were accurately identified with the correct ratio is 96%. The correlation degrees among the four kinds of compound formulae were calculated also,and it was found that for the two pairs of compound formula among the four kinds,their efficiency was directly proportional to their correlation degree. The results proved that dual index grade sequence individualized pattern recognition theory was suitable to accurately identify many kinds of traditional Chinese compound formulae composed of very similar composition simultaneously. Conclusion： The correlation degree may be a good parameter for theoretically evaluating the quality and medical efficiency of traditional Chinese compound formulae.

关 键 词：药效关联度 精确鉴别 个性化模式识别 双指标 指纹图谱 复方丹参滴丸 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]