基于数据挖掘的高脂血症中医处方用药规律研究  

Analysis on Medication Rules of TCM Prescriptions for Hyperlipidemia Based on Data Mining

作　　者：吴嘉瑞[1] 蔺梦娟 张晓朦[1] 张冰[1] 盛晓光[1] 

机构地区：[1]北京中医药大学,北京100102

出　　处：《世界中医药》2015年第6期917-920,共4页World Chinese Medicine

基　　金：国家科技支撑计划课题(编号:2007BAI10B01);北京市中医药科技发展基金课题(编号:JJ-2010-70);北京中医药大学科研创新团队项目资助(编号:2011-CXTD-14);北京中医药大学"重点学科"开放课题(编号:2013-ZDXKKF-19)

摘　　要：目的:分析高脂血症的中医处方用药规律。方法:收集治疗高脂血症的中医处方,在建立处方数据库的基础上,采用关联规则Apriori算法和复杂系统熵聚类等方法开展研究,确定处方中各种药物的使用频次及药物之间的关联规则等。结果:高频次药物包括泽泻、山楂、丹参、决明子、茯苓等;高频次药物组合包括"山楂,泽泻""山楂,丹参""丹参,泽泻"等;置信度较高的关联规则包括"何首乌→山楂""丹参,何首乌→山楂""何首乌,泽泻→山楂"等;新处方包括"枳壳,延胡索,瓜蒌皮,青皮""熟地黄,决明子,山药,何首乌,大黄"等。结论:处方用药多具健脾利湿化痰、活血化瘀清热之功,体现了中医痰瘀同治,标本兼顾的诊疗原则。Objective： To analyze the medication rules of prescriptions for hyperlipidemia. Methods： Based on the database built by the prescriptions for hyperlipidemia,the methods of association rules with apriori algorithm and complex system entropy cluster were used to achieve the frequency of medicines,association rules between drugs and others. Results： The data-mining results indicated that the highest frequency used Chinese medicine were Alismatis Rhizoma,Crataegi Fructus,Salviae Miltiorrhizae Radix et Rhizoma,Cassiae Semen,and Poria. The most frequent drug combinations were ＂Crataegi Fructus,Alismatis Rhizoma＂,＂Crataegi Fructus,Salviae Miltiorrhizae Radix et Rhizoma＂,and ＂Salviae Miltiorrhizae Radix et Rhizoma,Alismatis Rhizoma＂. The drugs with a high degree confidence coefficient of association rules included ＂Polygoni Multiflori Radix- Crataegi Fructus＂,＂Salviae Miltiorrhizae Radix et Rhizoma,Polygoni Multiflori Radix- Crataegi Fructus＂,and＂Polygoni Multiflori Radix,Alismatis Rhizoma- Crataegi Fructus＂. The new prescriptions included ＂Aurantii Fructus,Corydalis Rhizoma,Trichosanthis Pericarpium,Citri Reticulatae Pericarpium Viride＂,and＂Rehmanniae Radix Praeparata,Cassiae Semen,Dioscoreae Rhizoma,Polygoni Multiflori Radix,Rhei Radix et Rhizoma＂. Conclusion： The Chinese medicine applied in the prescriptions for hyperlipidemia mostly have the effects of invigorating the spleen,eliminating dampness,reducing phlegm,promoting blood circulation by removing blood stasis and clearing heat,which reflects the principles of synchronically treating phlegm and blood stasis,giving consideration to both the incidental and fundamental.

关 键 词：高脂血症 用药规律 关联规则 熵聚类 

分 类 号：R289[医药卫生—方剂学]