烷基-α-D-吡喃甘露糖苷中间体的合成  

Syntheses of Alkylα-D-Mannopyranoside Intermediates

作　　者：伍桂龙[1] 旷娜[1] 陈朗秋[1] 陈静[1] 

机构地区：[1]湘潭大学化学学院环境友好化学与应用省部共建教育部重点实验室,湖南湘潭411105

出　　处：《湘潭大学自然科学学报》2015年第2期75-79,共5页Natural Science Journal of Xiangtan University

基　　金：湖南省自然科学基金项目(14JJ2067;10JJ6023)

摘　　要：烷基-α-D-吡喃甘露糖苷是重要的表面活性剂和抗菌剂.以D-甘露糖为原料,经乙酰化、选择性脱C1位乙酰基、转化成三氯乙酰亚胺酯、与受体偶联和脱保护五步反应立体专一性地合成了八种烷基-α-D-吡喃甘露糖苷中间体,目标化合物的结构经氢谱和质谱分析得到了确证,方法有效并且产率高.Alkylα-D-mannopyranosides are important non-ionic surfactant and antimicrobial.Alkylα-Dmannopyranosides were stereospecifically synthesized through five consecutive steps including acetylation,selective deacetylation at the C1 position,conversion to trichloroacetimidate and coupling with acceptors.The structure of the target compound was confirmed by the 1 H NMR and MS analysis,the method is effective and practical,and the yield is high.

关 键 词：烷基-α-D-吡喃甘露糖苷 D-甘露糖 合成 

分 类 号：O629.13[理学—有机化学]