Non-HDL-C和AI对冠心病患者病情的评估价值  

Value of non-high-density lipoprotein cholesterol and atherosclerosis index for assessing the illness of patients with coronary heart disease

作　　者：王秋颖[1] 向良浩[1] 张伟民[1] 吴兴[1] 王鲁英[2] 

机构地区：[1]中国人民解放军第九二医院心血管内分泌科,福建南平353000 [2]中国人民解放军第九二医院胸心普外科,福建南平353000

出　　处：《海南医学》2015年第13期1909-1912,共4页Hainan Medical Journal

摘　　要：目的探讨非高密度脂蛋白(Non-HDL-C)和粥样动脉硬化指数(AI)评估冠心病病情的临床价值。方法以冠心病患者为病例组(398例),以健康者为对照组(150例),全自动生化分析仪检测并比较不同组别受试者的一般临床资料、血脂、血糖、Non-HDL-C、AI等指标。结果冠心病组年龄、BMI、血压、甘油三酯、Non-HDL-C、AI等均高于对照组(P<0.05);慢性冠心病组年龄、BMI、收缩压、甘油三酯、TC、LDL-C、HDL-C、空腹血糖、Non-HDL-C、AI等高于不稳定型心绞痛组、急性心肌梗死组(P<0.05);Non-HDL-C与AI具有正相关关系(r2=0.161 1,P<0.05);Non-HDL-C、AI均与年龄、HDL-C呈负相关,与LDL-C、TC、甘油三酯呈正相关(P<0.05);Non-HDL-C、AI与冠状动脉病变总分呈正相关(P<0.05)。结论冠心病患者的Non-DHL-C和AI水平明显高于对照组,且Non-DHL-C和AI水平越高,冠心病病变越严重。二者可用于评价冠心病病情严重程度。Objective To investigate the value of non-high-density lipoprotein cholesterol（non-HDL-C） and atherosclerosis index（AI） for determining the illness of the patients with coronary heart disease. Methods Patients with coronary artery disease（CHD group, n=398） and normal healthy people（control group, n=150） were selected and tested by automatic biochemical analyzer. The clinical data were compared and between the two groups, including blood lipid, blood sugar, non-HDL-C and AI. Results The age, body mass index（BMI）, blood pressure, triglycerides,non-HDL-C, AI of CHD group were higher than those of the control group（P〈0.05）. The age, BMI, systolic blood pressure, triglycerides, total cholesterol（TC）, low-density lipoprotein cholesterol（LDL-C）, high-density lipoprotein cholesterol（HDL-C）, fasting glucose, non-HDL-C, AI of chronic CHD group were higher than those of unstable angina group and acute myocardial infarction group（P〈0.05）. Non-HDL-C and AI had positive correlation（r2=0.161 1, P〈0.05）, and non-HDL-C, AI were negatively associated with age, HDL-C and positively correlated with LDL-C, TC, TG（P〈0.05）.Non-HDL-C, AI and coronary lesion scores were positively correlated（P〈0.05）. Conclusion Non-DHL-C and AI levels are significantly higher in patients with coronary heart disease than healthy people. The higher the non-DHL-C and AI levels are, the more severe the disease is. The two indexes can be used for evaluating the severity of coronary artery disease.

关 键 词：非高密度脂蛋白(Non-HDL-C) 粥样动脉硬化指数(AI) 冠心病 价值 

分 类 号：R541.4[医药卫生—心血管疾病]