双[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH_2)_n[CO_2Sn(CH_2CMe_2Ph)_3]_2(n=5,6)的合成、结构、热稳定性及生物活性  

Syntheses, Crystal Structures, Thermal Stability and Biological Activities of Two Bis[tri(2-methyl-2-phenyl)propyltin]dicarboxylates(CH_2)_n[CO_2Sn(CH_2CMe_2Ph)_3]_2(n=5,6)

作　　者：朱小明[1,2] 邝代治[1,2] 冯泳兰[1,2] 张复兴[1,2] 庾江喜[1,2] 蒋伍玖[1,2] 张志坚[3] 

机构地区：[1]衡阳师范学院化学与材料科学系 [2]功能金属有机材料湖南省普通高等学校重点实验室,衡阳421008 [3]衡阳师范学院生命科学系,衡阳421008

出　　处：《无机化学学报》2015年第7期1373-1379,共7页Chinese Journal of Inorganic Chemistry

基　　金：湖南省自然科学基金(No.13JJ3112;科技计划(No.2013TZ2025,2014NK3086,2014FJ3060);功能金属有机材料湖南省普通高校重点实验室开放基金(No.13K105,14K014,13K01-05,GN14K01);衡阳师范学院科学基金(No.12C45);湖南省重点学科基金;湖南省高校科技创新团队支持计划资助项目

摘　　要：氧化双[三(2-甲基-2-苯基)丙基]锡分别与庚二酸和辛二酸反应,合成了2个双[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2[(n=5(1),6(2)],经IR、1H和13C NMR、元素分析和X射线单晶衍射对化合物进行了表征。化合物属单斜晶系,空间群为P21/c。锡原子均为畸型四面体构型,化合物1以氢键作用形成一维链状结构,化合物2以氢键和C-H…π作用形成二维网状结构。化合物1和2在340℃以下具有良好的热稳定性,对人癌细胞Colo205、HepG2、MCF-7、Hela、NCI-H460均具有较好的体外抑制活性,且具有一定的抑菌活性。The two bis[tri（2-methyl-2-phenyl）propyltin]dicarboxylates （CH2）n[CO2Sn（CH2CMe2Ph）3]2 （n=5 （1）, 6 （2）） have been synthesized by the reaction of pimelic acid and suberic acid with bis[tri（2-methyl-2-phenyl）propyltin] oxide, respectively. IR, 1H and 13C NMR, elemental analysis and X-ray diffraction for the title complexes were presented. The two complexes belong to monoclinic, space group P21/c. The tin atoms have a distorted tetrahedral geometry. A 1D chain structure of complex 1 is generated by intermolecular hydrogen bonds and a 2D network structure of complex 2 is formed by C-H…… O and C-H…… 7r interactions. The thermal gravimetric analysis has showed that the complexes 1 and 2 are stable below 340 ℃. The two complexes showed strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460, and have antibacterial activity. CCDC： 1047097, 1; 1047098, 2.

关 键 词：双[三(2-甲基-2-苯基)丙基锡]二元羧酸酯 合成 晶体结构 生物活性 

分 类 号：O614.43[理学—无机化学]