两个吡咯酰腙铜配合物的制备、结构及抗肿瘤活性(英文)  

Syntheses, Characterizations and Antitumor Activities of Two Copper(Ⅱ) Complexes with an Acylhydrazone Ligand Bearing Pyrrole Unit

作　　者：韩学锋[1] 蔡红新[2] 贾磊[2] 吴伟娜[2] 张鑫[3] 徐君[2] 张照坡[2] 王元[2] 

机构地区：[1]河南理工大学人事处,焦作454000 [2]河南理工大学物理化学学院,焦作454000 [3]中国农业大学农业与生物技术学院,北京454000

出　　处：《无机化学学报》2015年第7期1453-1459,共7页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.21404033,21401046,21001040);河南省教育厅自然科学基金(No.12B150011,14B150029);河南理工大学博士基金(No.72515/086,61307/003);江苏省自然科学基金(No.BK20141122)资助项目

摘　　要：合成并通过X-射线单晶衍射表征了2个铜配合物[Cu(H2L)2(THF)](1)和[Cu2(L)Cl(CH3OH)]·H2O(2)(H3L=3,4-二甲基吡咯-5-甲酰基-2-甲酸乙酯-2-羟基-4-甲基苯甲酰腙)。结果表明在配合物1中,中心金属离子与周围2个提供N2O配位原子的酰腙阴离子和1个四氢呋喃分子配位,具有扭曲的四方锥配位构型。然而,在双核配合物2中,酰腙配体脱去3个质子,通过NO和N2O2配位原子分别桥联2个具有平面正方形配位构型的铜中心。2个配合物对人肺癌细胞A549,人食管癌细胞ECA109和人胃癌细胞SGC7901展现出显著的抗肿瘤活性。Two interesting copper（M） complexes,[Cu（HzL）2（THF）] （1） and[CuE（L）CI（CH3OH）].H20 （2） based on H3L {ethyl 5-[（2-hydroxyl-4-methylbenzoyl）amino-iminomethyl]-3,4-dimethyl-pyrrole-2-carboxylate} were synthesized and characterized by X-ray diffraction analyses. The results show that in complex 1, the copper（U） ion is surrounded by two mono-deprotonated acylhydrazone ligands with NO donor sets and one THF molecule, and thus possesses a distorted square pyramidal geometry. However, in binuclear complex 2, the acylhydrazone ligand is tri-deprotonated and bridges two copper（Ⅱ） ions with square-planar coordination geometry through NO and N202 atom sets, respectively. Both complexes have excellent antitumor activities towards A549, ECA109 and SGC7901 cancer cells. CCDC： 1040334, H3L·H2O·CH3CH2OH; 1040335, 1; 1040336, 2.

关 键 词：酰腙 铜(Ⅱ)配合物 吡咯 抗肿瘤活性 

分 类 号：O614.121[理学—无机化学]