组织工程化胆管的研究现状及展望  

Current Status and Prospect of Tissue-Engineered Bile Duct

作　　者：程瑶[1] 张杰[2] 程南生[1] 熊先泽[1] 

机构地区：[1]四川大学华西医院胆道外科,四川成都610041 [2]四川大学华西医院移植免疫实验室,四川成都610041

出　　处：《中国普外基础与临床杂志》2015年第7期879-883,共5页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金资助项目(项目编号:30972923);四川省科技支撑项目(项目编号:2011FZ0009)~~

摘　　要：目的总结近年来组织工程化胆管的研究进展。方法采用文献复习的方法,对有关组织工程胆管的文献加以综述。结果近年来组织工程化胆管在支架材料、种子细胞、生长因子等方面研究取得了突破性进展,但是组织工程化胆管目前还处于动物实验研究阶段,还不能直接应用于临床。结论组织工程化胆管的研究已然成为当下的热点,随着材料科学和细胞生物学的飞速发展,组织工程化胆管的基础研究和临床应用将会得到更加深入的研究和推广,有希望为胆管缺损和胆管狭窄的患者带来全新治疗理念和治疗措施。Objective To summarize the research progress of tissue- engineered bile duct in recent years. Methods The related literatures about the tissue-engineered bile duct were reviewed. Results In recent years, the research of tissue-engineered bile duct has made a breakthrough in scaffold materials, seed cells, growth factors etc. However, the tissue-engineered bile duct is still in the research stage of animal experiments, which can not be directly applied to clinical practice. Conclusions The research of tissue-engineered bile duct becomes popular at present. With the rapid development of materials science and cell biology, the basic research and clinical application of tissue-engineered duct will be more in-depth research and extension, which might bring new ideas and therapeutic measures for patients with biliary defect or stenosis.

关 键 词：组织工程 胆管 支架材料 种子细胞 生长因子 

分 类 号：R318.08[医药卫生—生物医学工程] R575.7[医药卫生—基础医学]