α黑素细胞刺激素类似物及其诱导剂治疗白癜风的研究进展  

Alpha-melanocyte stimulating hormone analogues and their inducers for the treatment of vitiligo

作　　者：王晨[1] 张海萍[1] 

机构地区：[1]首都医科大学宣武医院皮肤性病科,北京100053

出　　处：《国际皮肤性病学杂志》2015年第4期230-232,共3页International Journal of Dermatology and Venereology

摘　　要：α黑素细胞刺激素作为黑素细胞刺激素中作用最强的一种内源性小分子神经内分泌免疫调节肽,主要在脑垂体中产生.α黑素细胞刺激素可以促进黑素细胞增殖、产生黑素小体以及通过小眼畸形相关转录因子调节黑素细胞分化,引起皮肤色素沉着.研究发现,白癜风患者表皮及血浆中的α黑素细胞刺激素浓度降低.临床推荐α黑素细胞刺激素的类似物afamelanotide和性类固醇甲状腺激素治疗白癜风,性类固醇甲状腺激素可诱导黑素细胞α黑素细胞刺激素的表达,两者均可利用α黑素细胞刺激素作用于黑素细胞的原理而治疗白癜风.Alpha-melanocyte stimulating hormone （α-MSH）,the strongest endogenous immunomodulatory small-molecule neuroendocrine peptide among melanocyte stimulating hormones,is mainly produced in the pituitary gland.α-MSH can promote melanocytes to proliferate and produce melanosomes,regulate the differentiation of melanocytes through the microphthalmia-associated transcription factor,and finally cause skin pigmentation.Many studies have shown that α-MSH levels are decreased in the epidermis and sera in patients with vitiligo.The α-MSH analogue afamelanotide,which can induce the expression of α-MSH by melanocytes,and the sex steroid thyroid hormone metharmon-F,both can be used to treat vitiligo through action on melanocytes,and have been lately recommended for the treatment of vitiligo at clinics.

关 键 词：α促黑素 白癜风 性类固醇甲状腺激素 小眼畸形相关转录因子 α-MSH衍生物 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]